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Developmental signalling (PDB): 44 3D models

DNA, RNA, nucleic-acid drugs, gene editing, proteins and 300+ real PDB structures (real sizes 1–100 nm). Each one is a ready-made 3D model you can turn, recolour and place in a figure — open BioDiorama and type its name in the Library search.

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Wnt8 bound to the Frizzled-8 CRD (Xenopus) — Crystal structure of xwnt8 in complex with the cysteine-rich domain of frizzled 8 — X-ray structure, 2012 (PDB 4F0A), downloaded from the RCSB Protein Data Bank.
Wnt3 bound to the Frizzled-8 CRD — Wnt signaling complex — X-ray structure, 2019 (PDB 6AHY), downloaded from the RCSB Protein Data Bank.
Notch1 bound to Delta-like 4 — Complex of notch1 (egf11-13) bound to delta-like 4 (n-egf1) — X-ray structure, 2015 (PDB 4XL1), downloaded from the RCSB Protein Data Bank.
Notch1 bound to Jagged1 — Complex of notch1(egf8-12) bound to jagged1(n-egf3) — X-ray structure, 2017 (PDB 5UK5), downloaded from the RCSB Protein Data Bank.
Notch transcription complex (NICD–CSL–MAML) on HES1 DNA — Crystal structure of activated notch, csl and maml on hes-1 promoter dna sequence — X-ray structure, 2006 (PDB 2F8X), downloaded from the RCSB Protein Data Bank.
CSL–Notch–Mastermind complex on DNA (C. elegans) — Crystal structure of the csl-notch-mastermind ternary complex bound to dna — X-ray structure, 2006 (PDB 2FO1), downloaded from the RCSB Protein Data Bank.
BMP-7 held by Noggin — Crystal structure of bone morphogenetic protein-7 (bmp-7) in complex with the secreted antagonist noggin — X-ray structure, 2002 (PDB 1M4U), downloaded from the RCSB Protein Data Bank.
BMP-2 with its type I and type II receptors — Crystal structure of a ternary ligand-receptor complex of bmp-2 — X-ray structure, 2007 (PDB 2H62), downloaded from the RCSB Protein Data Bank.
RGMb–BMP-2–neogenin complex — Crystal structure of the ternary rgmb-bmp2-neo1 complex — X-ray structure, 2015 (PDB 4UI2), downloaded from the RCSB Protein Data Bank.
Myostatin trapped by follistatin — Crystal structure of the myostatin:follistatin 288 complex — X-ray structure, 2009 (PDB 3HH2), downloaded from the RCSB Protein Data Bank.
Activin A trapped by follistatin — The structure of the follistatin:activin complex — X-ray structure, 2005 (PDB 2B0U), downloaded from the RCSB Protein Data Bank.
Activin A bound to ActRIIB — Crystal structure of activin a bound to the ecd of actriib p41 — X-ray structure, 2003 (PDB 1NYS), downloaded from the RCSB Protein Data Bank.
TGF-β3 with TβRI and TβRII — Structural basis for cooperative assembly of the tgf-beta signaling complex — X-ray structure, 2008 (PDB 2PJY), downloaded from the RCSB Protein Data Bank.
Anti-Müllerian hormone bound to AMHR2 — Structure of amh bound to amhr2-ecd — X-ray structure, 2021 (PDB 7L0J), downloaded from the RCSB Protein Data Bank.
Sclerostin (Wnt antagonist of bone) — Characterisation of the structural features and interactions of sclerostin — NMR structure, 2009 (PDB 2K8P), downloaded from the RCSB Protein Data Bank.
Sonic hedgehog N-terminal signalling domain — Crystal structure of human sonic hedgehog n-terminal domain — X-ray structure, 2010 (PDB 3M1N), downloaded from the RCSB Protein Data Bank.
Patched1 bound to Sonic hedgehog — Cryo-em structure of human ptch1 and shhn complex — Cryo-EM structure, 2018 (PDB 6DMY), downloaded from the RCSB Protein Data Bank.
Sonic hedgehog bound to HHIP — Crystal structure of the complex between human hedgehog-interacting protein hip and sonic hedgehog — X-ray structure, 2009 (PDB 2WFX), downloaded from the RCSB Protein Data Bank.
Sonic hedgehog bound to CDO — Crystal structure of sonic hedgehog bound to the third fniii domain of cdo — X-ray structure, 2008 (PDB 3D1M), downloaded from the RCSB Protein Data Bank.
Smoothened with cholesterol — Structure of human smoothened in complex with cholesterol — X-ray structure, 2016 (PDB 5L7D), downloaded from the RCSB Protein Data Bank.
GLI zinc fingers on DNA — Five-finger gli/dna complex — X-ray structure, 1993 (PDB 2GLI), downloaded from the RCSB Protein Data Bank.
R-spondin 1 bridging LGR5 and RNF43 — Crystal structure of human lgr5-rspo1-rnf43 — X-ray structure, 2013 (PDB 4KNG), downloaded from the RCSB Protein Data Bank.
Dickkopf-1 bound to LRP6 — Structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6 — X-ray structure, 2011 (PDB 3S2K), downloaded from the RCSB Protein Data Bank.
β-catenin bound to TCF4 — Crystal structure of beta-catenin and htcf-4 — X-ray structure, 2001 (PDB 1JDH), downloaded from the RCSB Protein Data Bank.
β-catenin bound to Axin — Beta-catenin binding domain of axin in complex with beta-catenin — X-ray structure, 2003 (PDB 1QZ7), downloaded from the RCSB Protein Data Bank.
FGF8b bound to FGFR2c — Crystal structure of fibroblast growth factor (fgf)8b in complex with fgf receptor (fgfr) 2c — X-ray structure, 2006 (PDB 2FDB), downloaded from the RCSB Protein Data Bank.
EphB2 bound to ephrin-B2 — Crystal structure of the ephb2-ephrinb2 complex — X-ray structure, 2002 (PDB 1KGY), downloaded from the RCSB Protein Data Bank.
Slit2 bound to Robo1 — Complex between the second lrr domain of slit2 and the first ig domain from robo1 — X-ray structure, 2007 (PDB 2V9T), downloaded from the RCSB Protein Data Bank.
Netrin-1 bound to DCC — The crystal structure of a fragment of netrin-1 in complex with fn5-fn6 of dcc — X-ray structure, 2014 (PDB 4URT), downloaded from the RCSB Protein Data Bank.
Semaphorin 6A bound to Plexin A2 — Plexin a2 in complex with semaphorin 6a — X-ray structure, 2010 (PDB 3OKY), downloaded from the RCSB Protein Data Bank.
RAR–RXR on a retinoic acid response element — Structure of the rxr/rar dna-binding domain heterodimer in complex with the retinoic acid response element dr1 — X-ray structure, 2000 (PDB 1DSZ), downloaded from the RCSB Protein Data Bank.
Engrailed homeodomain on DNA — Crystal structure of an engrailed homeodomain-dna complex at 2.8 å resolution — X-ray structure, 1992 (PDB 1HDD), downloaded from the RCSB Protein Data Bank.
Bicoid homeodomain on DNA — Nmr solution structure of the bicoid homeodomain bound to the consensus dna binding site taatcc — NMR structure, 2006 (PDB 1ZQ3), downloaded from the RCSB Protein Data Bank.
HoxA9–Pbx1 homeodomains on DNA — Crystal structure of hoxa9 and pbx1 homeodomains bound to dna — X-ray structure, 2003 (PDB 1PUF), downloaded from the RCSB Protein Data Bank.
HoxB1–Pbx1 homeodomains on DNA — Pbx1, homeobox protein hox-b1/dna ternary complex — X-ray structure, 1999 (PDB 1B72), downloaded from the RCSB Protein Data Bank.
Paired domain on DNA (Drosophila Prd) — Crystal structure of a paired domain-dna complex at 2.5 å resolution — X-ray structure, 1995 (PDB 1PDN), downloaded from the RCSB Protein Data Bank.
Pax6 paired domain on DNA — Crystal structure of the human pax-6 paired domain-dna complex — X-ray structure, 1999 (PDB 6PAX), downloaded from the RCSB Protein Data Bank.
Sox2 and Oct1 on the FGF4 enhancer — Crystal structure of a pou/hmg/dna ternary complex — X-ray structure, 2003 (PDB 1GT0), downloaded from the RCSB Protein Data Bank.
Brachyury T-domain on DNA (Xenopus) — T domain from xenopus laevis bound to dna — X-ray structure, 1998 (PDB 1XBR), downloaded from the RCSB Protein Data Bank.
Vasa helicase unwinding RNA (Drosophila) — Structural basis for rna unwinding by the dead-box protein drosophila vasa — X-ray structure, 2006 (PDB 2DB3), downloaded from the RCSB Protein Data Bank.
Oskar LOTUS domain bound to Vasa — Structure of the lotus domain of oskar in complex with the c-terminal reca-like domain of vasa — X-ray structure, 2017 (PDB 5NT7), downloaded from the RCSB Protein Data Bank.
Siwi (PIWI) with a piRNA (silkworm) — Crystal structure of silkworm piwi-clade argonaute siwi bound to pirna — X-ray structure, 2016 (PDB 5GUH), downloaded from the RCSB Protein Data Bank.
Fibronectin type III repeats 7–10 (RGD loop) — Fragment of human fibronectin encompassing type-iii repeats 7 through 10 — X-ray structure, 1996 (PDB 1FNF), downloaded from the RCSB Protein Data Bank.
Lysyl oxidase-like 2 (collagen cross-linking) — Crystal structure of human lysyl oxidase-like 2 (hloxl2) in a precursor state — X-ray structure, 2018 (PDB 5ZE3), downloaded from the RCSB Protein Data Bank.