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Enzymes & drug targets (PDB): 195 3D models

DNA, RNA, nucleic-acid drugs, gene editing, proteins and 300+ real PDB structures (real sizes 1–100 nm). Each one is a ready-made 3D model you can turn, recolour and place in a figure — open BioDioRama and type its name in the Library search.

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Oxyhemoglobin — Structure of human oxyhaemoglobin at 2.1 angstroms resolution — X-ray structure, 1983 (PDB 1HHO), downloaded from the RCSB Protein Data Bank.
Furin with inhibitory nanobody — X-ray structure of furin in complex with the inhibitory antibody nb14 — X-ray structure, 2016 (PDB 5JMO), downloaded from the RCSB Protein Data Bank.
Hemoglobin (deoxy) — Deoxy human hemoglobin — X-ray structure, 1998 (PDB 1A3N), downloaded from the RCSB Protein Data Bank.
Hemoglobin — The crystal structure of human deoxyhaemoglobin at 1.74 angstroms resolution — X-ray structure, 1984 (PDB 2HHB), downloaded from the RCSB Protein Data Bank.
Myoglobin — The stereochemistry of the protein myoglobin — X-ray structure, 1976 (PDB 1MBN), downloaded from the RCSB Protein Data Bank.
Green fluorescent protein (GFP) — Green fluorescent protein from aequorea victoria — X-ray structure, 1996 (PDB 1EMA), downloaded from the RCSB Protein Data Bank.
GFP — Structure of green fluorescent protein — X-ray structure, 1997 (PDB 1GFL), downloaded from the RCSB Protein Data Bank.
mCherry — Crystal structure of mcherry — X-ray structure, 2006 (PDB 2H5Q), downloaded from the RCSB Protein Data Bank.
Yellow fluorescent protein — Structure of yellow-emission variant of gfp — X-ray structure, 1998 (PDB 1YFP), downloaded from the RCSB Protein Data Bank.
Firefly luciferase — Firefly luciferase — X-ray structure, 1997 (PDB 1LCI), downloaded from the RCSB Protein Data Bank.
Insulin — The structure of 2zn pig insulin crystals at 1.5 angstroms resolution — X-ray structure, 1990 (PDB 4INS), downloaded from the RCSB Protein Data Bank.
Insulin (hexamer) — Insulin — X-ray structure, 1998 (PDB 1ZNI), downloaded from the RCSB Protein Data Bank.
Glucagon — X-ray analysis of glucagon and its relationship to receptor binding — X-ray structure, 1977 (PDB 1GCN), downloaded from the RCSB Protein Data Bank.
GLP-1 receptor with Gs protein — Cryo-em structure of the activated glucagon-like peptide-1 receptor in complex with g protein — cryo-EM structure, 2017 (PDB 5VAI), downloaded from the RCSB Protein Data Bank.
GLP-1 receptor ECD with semaglutide — Crystal structure of semaglutide peptide backbone in complex with the glp-1 receptor extracellular domain — X-ray structure, 2015 (PDB 4ZGM), downloaded from the RCSB Protein Data Bank.
β2-adrenergic receptor — High resolution crystal structure of human b2-adrenergic g protein-coupled receptor. — X-ray structure, 2007 (PDB 2RH1), downloaded from the RCSB Protein Data Bank.
β2-adrenergic receptor–Gs complex — Crystal structure of the beta2 adrenergic receptor-gs protein complex — X-ray structure, 2011 (PDB 3SN6), downloaded from the RCSB Protein Data Bank.
Rhodopsin — Crystal structure of bovine rhodopsin — X-ray structure, 2000 (PDB 1F88), downloaded from the RCSB Protein Data Bank.
Acetylcholinesterase — Native acetylcholinesterase (e.c. 3.1.1.7) from torpedo californica at 1.8a resolution — X-ray structure, 2000 (PDB 1EA5), downloaded from the RCSB Protein Data Bank.
Acetylcholinesterase with donepezil — Crystal structure of recombinant human acetylcholinesterase in complex with donepezil — X-ray structure, 2012 (PDB 4EY7), downloaded from the RCSB Protein Data Bank.
HMG-CoA reductase with atorvastatin — Complex of the catalytic portion of human hmg-coa reductase with atorvastatin — X-ray structure, 2001 (PDB 1HWK), downloaded from the RCSB Protein Data Bank.
COX-2 with inhibitor — Cyclooxygenase-2 (prostaglandin synthase-2) complexed with a selective inhibitor, sc-558 — X-ray structure, 1997 (PDB 1CX2), downloaded from the RCSB Protein Data Bank.
Prostaglandin H2 synthase-1 (COX-1) — The x-ray crystal structure of the membrane protein prostaglandin h2 synthase-1 — X-ray structure, 1995 (PDB 1PRH), downloaded from the RCSB Protein Data Bank.
Carbonic anhydrase II — Refined structure of human carbonic anhydrase ii at 2.0 angstroms resolution — X-ray structure, 1990 (PDB 1CA2), downloaded from the RCSB Protein Data Bank.
Trypsin — On the disordered activation domain in trypsinogen. chemical labelling and low-temperature crystallography — X-ray structure, 1982 (PDB 2PTN), downloaded from the RCSB Protein Data Bank.
Chymotrypsin — Structure of alpha-*chymotrypsin refined at 1.68 angstroms resolution — X-ray structure, 1985 (PDB 4CHA), downloaded from the RCSB Protein Data Bank.
Thrombin — The refined 1.9 angstroms crystal structure of human alpha-thrombin: interaction with d-phe-pro-arg chloromethylketone and significance o… — X-ray structure, 1994 (PDB 1PPB), downloaded from the RCSB Protein Data Bank.
Factor Xa with rivaroxaban — Factor xa in complex with bay59-7939 — X-ray structure, 2008 (PDB 2W26), downloaded from the RCSB Protein Data Bank.
EGFR kinase with erlotinib — Epidermal growth factor receptor tyrosine kinase domain with 4-anilinoquinazoline inhibitor erlotinib — X-ray structure, 2002 (PDB 1M17), downloaded from the RCSB Protein Data Bank.
ABL kinase with imatinib — Crystal structure of the c-abl kinase domain in complex with sti-571. — X-ray structure, 2001 (PDB 1IEP), downloaded from the RCSB Protein Data Bank.
BRAF V600E with vemurafenib — B-raf kinase v600e oncogenic mutant in complex with plx4032 — X-ray structure, 2010 (PDB 3OG7), downloaded from the RCSB Protein Data Bank.
CDK2 — Human cyclin-dependent kinase 2 — X-ray structure, 1996 (PDB 1HCK), downloaded from the RCSB Protein Data Bank.
Protein kinase A — 2.2 angstrom refined crystal structure of the catalytic subunit of camp-dependent protein kinase complexed with mnatp and a peptide inhib… — X-ray structure, 1993 (PDB 1ATP), downloaded from the RCSB Protein Data Bank.
Estrogen receptor with estradiol — Human estrogen receptor ligand-binding domain in complex with 17beta-estradiol — X-ray structure, 1998 (PDB 1ERE), downloaded from the RCSB Protein Data Bank.
Estrogen receptor with 4-hydroxytamoxifen — Human estrogen receptor alpha ligand-binding domain in complex with 4-hydroxytamoxifen — X-ray structure, 1999 (PDB 3ERT), downloaded from the RCSB Protein Data Bank.
Glucocorticoid receptor — Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a tif2 coactiv… — X-ray structure, 2003 (PDB 1M2Z), downloaded from the RCSB Protein Data Bank.
Dihydrofolate reductase with methotrexate — Crystal structures of escherichia coli and lactobacillus casei dihydrofolate reductase refined at 1.7 angstroms resolution. i. general fe… — X-ray structure, 1982 (PDB 4DFR), downloaded from the RCSB Protein Data Bank.
Tubulin with taxol — Refined structure of alpha-beta tubulin from zinc-induced sheets stabilized with taxol — electron crystallography structure, 2001 (PDB 1JFF), downloaded from the RCSB Protein Data Bank.
Tubulin with colchicine — Tubulin-colchicine: stathmin-like domain complex — X-ray structure, 2004 (PDB 1SA0), downloaded from the RCSB Protein Data Bank.
Topoisomerase IIβ with etoposide — Human topoisomerase iibeta in complex with dna and etoposide — X-ray structure, 2011 (PDB 3QX3), downloaded from the RCSB Protein Data Bank.
20S proteasome — Crystal structure of the 20s proteasome from yeast at 2.4 angstroms resolution — X-ray structure, 1998 (PDB 1RYP), downloaded from the RCSB Protein Data Bank.
20S proteasome with bortezomib — Crystal structure of the yeast 20s proteasome in complex with bortezomib — X-ray structure, 2006 (PDB 2F16), downloaded from the RCSB Protein Data Bank.
F1-ATPase — Bovine mitochondrial f1-atpase — X-ray structure, 1996 (PDB 1BMF), downloaded from the RCSB Protein Data Bank.
GroEL–GroES chaperonin — Crystal structure of the asymmetric chaperonin complex groel/groes/(adp)7 — X-ray structure, 1997 (PDB 1AON), downloaded from the RCSB Protein Data Bank.
Hsp90 — Crystal structure of an hsp90-sba1 closed chaperone complex — X-ray structure, 2006 (PDB 2CG9), downloaded from the RCSB Protein Data Bank.
Lactate dehydrogenase — Human muscle l-lactate dehydrogenase m chain, ternary complex with nadh and oxamate — X-ray structure, 2001 (PDB 1I10), downloaded from the RCSB Protein Data Bank.
GAPDH — Crystal structure of human placental glyceraldehyde-3-phosphate dehydrogenase at 1.75 resolution — X-ray structure, 2005 (PDB 1U8F), downloaded from the RCSB Protein Data Bank.
Triose phosphate isomerase — Structure of the triosephosphate isomerase-phosphoglycolohydroxamate complex: an analogue of the intermediate on the reaction pathway — X-ray structure, 1993 (PDB 7TIM), downloaded from the RCSB Protein Data Bank.
Citrate synthase — Crystallographic refinement and atomic models of two different forms of citrate synthase at 2.7 and 1.7 angstroms resolution — X-ray structure, 1984 (PDB 1CTS), downloaded from the RCSB Protein Data Bank.
RuBisCO — Activated spinach rubisco complexed with 2-carboxyarabinitol bisphosphate — X-ray structure, 1996 (PDB 8RUC), downloaded from the RCSB Protein Data Bank.
Cytochrome c — High-resolution three-dimensional structure of horse heart cytochrome c — X-ray structure, 1994 (PDB 1HRC), downloaded from the RCSB Protein Data Bank.
Cytochrome c oxidase — Structure of bovine heart cytochrome c oxidase at the fully oxidized state — X-ray structure, 1996 (PDB 1OCC), downloaded from the RCSB Protein Data Bank.
Superoxide dismutase — Determination and analysis of the 2 angstrom structure of copper, zinc superoxide dismutase — X-ray structure, 1980 (PDB 2SOD), downloaded from the RCSB Protein Data Bank.
Horseradish peroxidase — Recombinant horseradish peroxidase c1a — X-ray structure, 1998 (PDB 1ATJ), downloaded from the RCSB Protein Data Bank.
Glucose oxidase — Glucose oxidase from apergillus niger — X-ray structure, 1999 (PDB 1CF3), downloaded from the RCSB Protein Data Bank.
Lipase B (Candida antarctica) — The sequence, crystal structure determination and refinement of two crystal forms of lipase b from candida antarctica — X-ray structure, 1994 (PDB 1TCA), downloaded from the RCSB Protein Data Bank.
Papain — Structure of papain refined at 1.65 angstroms resolution — X-ray structure, 1986 (PDB 9PAP), downloaded from the RCSB Protein Data Bank.
Pepsin — The molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 angstroms resolution — X-ray structure, 1990 (PDB 4PEP), downloaded from the RCSB Protein Data Bank.
α-Amylase — Human salivary amylase — X-ray structure, 1996 (PDB 1SMD), downloaded from the RCSB Protein Data Bank.
β-Galactosidase — E. coli (lacz) beta-galactosidase in complex with galactose — X-ray structure, 2001 (PDB 1JZ7), downloaded from the RCSB Protein Data Bank.
Nitrogenase — Nitrogenase complex from azotobacter vinelandii stabilized by adp-tetrafluoroaluminate — X-ray structure, 1997 (PDB 1N2C), downloaded from the RCSB Protein Data Bank.
p53 DNA-binding domain — P53 core domain in complex with dna — X-ray structure, 1996 (PDB 1TSR), downloaded from the RCSB Protein Data Bank.
MDM2 bound to p53 peptide — Mdm2 bound to the transactivation domain of p53 — X-ray structure, 1997 (PDB 1YCR), downloaded from the RCSB Protein Data Bank.
Ras — Refined crystal structure of the triphosphate conformation of h-ras p21 at 1.35 angstroms resolution: implications for the mechanism of g… — X-ray structure, 1992 (PDB 5P21), downloaded from the RCSB Protein Data Bank.
KRAS G12C with sotorasib — Crystal structure of human kras g12c covalently bound to amg 510 — X-ray structure, 2019 (PDB 6OIM), downloaded from the RCSB Protein Data Bank.
BCL-2 with venetoclax — crystal structure of bcl-2 with venetoclax — X-ray structure, 2019 (PDB 6O0K), downloaded from the RCSB Protein Data Bank.
BRD4 with JQ1 — Crystal structure of the first bromodomain of human brd4 in complex with the inhibitor jq1 — X-ray structure, 2010 (PDB 3MXF), downloaded from the RCSB Protein Data Bank.
HDAC8 — Crystal structure of human hdac8 complexed with trichostatin a — X-ray structure, 2004 (PDB 1T64), downloaded from the RCSB Protein Data Bank.
Serum albumin with ibuprofen — Human serum albumin complexed with ibuprofen — X-ray structure, 2005 (PDB 2BXG), downloaded from the RCSB Protein Data Bank.
HIV protease with inhibitor — Rational design of potent, bioavailable, nonpeptide cyclic ureas as hiv protease inhibitors — X-ray structure, 1995 (PDB 1HVR), downloaded from the RCSB Protein Data Bank.
μ-opioid receptor — Crystal structure of the mu-opioid receptor bound to a morphinan antagonist — X-ray structure, 2012 (PDB 4DKL), downloaded from the RCSB Protein Data Bank.
Insulin receptor kinase — Crystal structure of the tyrosine kinase domain of the human insulin receptor — X-ray structure, 1995 (PDB 1IRK), downloaded from the RCSB Protein Data Bank.
Transducin (G protein) — Heterotrimeric complex of a gt-alpha/gi-alpha chimera and the gt-beta-gamma subunits — X-ray structure, 1997 (PDB 1GOT), downloaded from the RCSB Protein Data Bank.
Gi protein heterotrimer — G protein heterotrimer gi_alpha_1 beta_1 gamma_2 with gdp bound — X-ray structure, 1997 (PDB 1GP2), downloaded from the RCSB Protein Data Bank.
MMP-2 (gelatinase A) — Gelatinase a (full-length) — X-ray structure, 1999 (PDB 1CK7), downloaded from the RCSB Protein Data Bank.
MMP-9 (gelatinase B) — Crystal structure of human matrix metalloproteinase mmp9 (gelatinase b). — X-ray structure, 2002 (PDB 1L6J), downloaded from the RCSB Protein Data Bank.
Cathepsin B — The refined 2.15 angstroms x-ray crystal structure of human liver cathepsin b: the structural basis for its specificity — X-ray structure, 1995 (PDB 1HUC), downloaded from the RCSB Protein Data Bank.
Hyaluronidase (bee venom) — Crystal structure (monoclinic) of bee venom hyaluronidase — X-ray structure, 2001 (PDB 1FCQ), downloaded from the RCSB Protein Data Bank.
β-Glucuronidase — Human beta-glucuronidase at 2.6 a resolution — X-ray structure, 1997 (PDB 1BHG), downloaded from the RCSB Protein Data Bank.
Cytochrome P450 3A4 — Crystal structure of human microsomal p450 3a4 — X-ray structure, 2004 (PDB 1TQN), downloaded from the RCSB Protein Data Bank.
Carboxylesterase 1 — Crystal structure of human liver carboxylesterase in complex with tacrine — X-ray structure, 2003 (PDB 1MX1), downloaded from the RCSB Protein Data Bank.
Nitroreductase — A minor fmn-dependent nitroreductase from escherichia coli b — X-ray structure, 2000 (PDB 1DS7), downloaded from the RCSB Protein Data Bank.
Glutathione S-transferase — Glutathione transferase a1-1 complexed with an ethacrynic acid glutathione conjugate (mutant r15k) — X-ray structure, 1995 (PDB 1GSE), downloaded from the RCSB Protein Data Bank.
Creatine kinase — Crystal structure of chicken brain-type creatine kinase at 1.41 angstrom resolution — X-ray structure, 1999 (PDB 1QH4), downloaded from the RCSB Protein Data Bank.
HIV protease with amprenavir — Crystal structure of hiv-1 protease in complex with vx-478, a potent and orally bioavailable inhibitor of the enzyme — X-ray structure, 1995 (PDB 1HPV), downloaded from the RCSB Protein Data Bank.
Sickle-cell hemoglobin (HbS) — The high resolution crystal structure of deoxyhemoglobin s — X-ray structure, 1997 (PDB 2HBS), downloaded from the RCSB Protein Data Bank.
Hemoglobin (oxy) — Oxy t state haemoglobin - oxygen bound at all four haems — X-ray structure, 2002 (PDB 1GZX), downloaded from the RCSB Protein Data Bank.
Deoxyhemoglobin — The crystal structure of human deoxyhaemoglobin at 1.74 angstroms resolution — X-ray structure, 1984 (PDB 4HHB), downloaded from the RCSB Protein Data Bank.
Hemoglobin with drug — Hemoglobin (val beta1 met, trp beta37 tyr) mutant — X-ray structure, 1998 (PDB 1A00), downloaded from the RCSB Protein Data Bank.
Dopamine D3 receptor — Structure of the human dopamine d3 receptor in complex with eticlopride — X-ray structure, 2010 (PDB 3PBL), downloaded from the RCSB Protein Data Bank.
Adenosine A2A receptor with antagonist — Crystal structure of the chimeric protein of a2aar-bril in complex with zm241385 at 1.8a resolution — X-ray structure, 2012 (PDB 4EIY), downloaded from the RCSB Protein Data Bank.
μ-opioid receptor (active) — Crystal structure of active mu-opioid receptor bound to the agonist bu72 — X-ray structure, 2015 (PDB 5C1M), downloaded from the RCSB Protein Data Bank.
5-HT1B receptor — Crystal structure of the chimeric protein of 5-ht1b-bril in complex with ergotamine (psi community target) — X-ray structure, 2013 (PDB 4IAR), downloaded from the RCSB Protein Data Bank.
μ-opioid receptor with Gi — Mu opioid receptor-gi protein complex — cryo-EM structure, 2018 (PDB 6DDE), downloaded from the RCSB Protein Data Bank.
A2A receptor — The 2.6 a crystal structure of a human a2a adenosine receptor bound to zm241385. — X-ray structure, 2008 (PDB 3EML), downloaded from the RCSB Protein Data Bank.
κ-opioid receptor — Structure of the human kappa opioid receptor in complex with jdtic — X-ray structure, 2012 (PDB 4DJH), downloaded from the RCSB Protein Data Bank.
Angiotensin II type 2 receptor — Xfel structure of human angiotensin ii type 2 receptor (monoclinic form) in complex with compound 1 (n-benzyl-n-(2-ethyl-4-oxo-3-{[2'-(2h… — X-ray structure, 2017 (PDB 5UNF), downloaded from the RCSB Protein Data Bank.
CB1 receptor — Crystal structure of the human cannabinoid receptor cb1 — X-ray structure, 2016 (PDB 5TGZ), downloaded from the RCSB Protein Data Bank.
Adenosine receptor with Gs — Cryo-em structure of the adenosine a2a receptor bound to a minigs heterotrimer — cryo-EM structure, 2018 (PDB 6GDG), downloaded from the RCSB Protein Data Bank.
EGFR kinase — Tyrosine kinase domain from epidermal growth factor receptor — X-ray structure, 2002 (PDB 1M14), downloaded from the RCSB Protein Data Bank.
EGFR with gefitinib — Crystal structure of egfr kinase domain in complex with iressa — X-ray structure, 2007 (PDB 2ITY), downloaded from the RCSB Protein Data Bank.
EGFR with erlotinib — Crystal structure of the inactive egfr tyrosine kinase domain with erlotinib — X-ray structure, 2012 (PDB 4HJO), downloaded from the RCSB Protein Data Bank.
ABL with imatinib — Human abl kinase domain in complex with imatinib (sti571, glivec) — X-ray structure, 2007 (PDB 2HYY), downloaded from the RCSB Protein Data Bank.
ABL with nilotinib — Human abl kinase in complex with nilotinib — X-ray structure, 2008 (PDB 3CS9), downloaded from the RCSB Protein Data Bank.
ABL with dasatinib — X-ray crystal structure of dasatinib (bms-354825) bound to activated abl kinase domain — X-ray structure, 2006 (PDB 2GQG), downloaded from the RCSB Protein Data Bank.
BRAF with sorafenib — The complex of wild type b-raf and bay439006. — X-ray structure, 2004 (PDB 1UWH), downloaded from the RCSB Protein Data Bank.
MEK1 with trametinib — Crystal structure of the braf:mek1 complex — X-ray structure, 2014 (PDB 4MNE), downloaded from the RCSB Protein Data Bank.
Sphingosine-1-phosphate receptor 1 — Crystal structure of a lipid g protein-coupled receptor at 2.80a — X-ray structure, 2012 (PDB 3V2Y), downloaded from the RCSB Protein Data Bank.
Human 26S proteasome — Structural basis for dynamic regulation of the human 26s proteasome — cryo-EM structure, 2016 (PDB 5T0J), downloaded from the RCSB Protein Data Bank.
ALK with lorlatinib — Structure of the human anaplastic lymphoma kinase in complex with pf- 06463922 ((10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16… — X-ray structure, 2014 (PDB 4CLI), downloaded from the RCSB Protein Data Bank.
ALK with crizotinib — Structure of the human anaplastic lymphoma kinase in complex with crizotinib (pf-02341066) — X-ray structure, 2010 (PDB 2XP2), downloaded from the RCSB Protein Data Bank.
EGFR kinase with TAK-285 — Egfr kinase domain complexed with tak-285 — X-ray structure, 2011 (PDB 3POZ), downloaded from the RCSB Protein Data Bank.
PI3Kα with alpelisib — Co-crystal structures of the lipid kinase pi3k alpha with pan and isoform selective inhibitors — X-ray structure, 2014 (PDB 4JPS), downloaded from the RCSB Protein Data Bank.
mTOR — mtor kinase structure, mechanism and regulation. — X-ray structure, 2013 (PDB 4JSV), downloaded from the RCSB Protein Data Bank.
FKBP12–rapamycin–FRB — The structure of the immunophilin-immunosuppressant fkbp12-rapamycin complex interacting with human frap — X-ray structure, 1997 (PDB 1FAP), downloaded from the RCSB Protein Data Bank.
FKBP12 with FK506 — Atomic structure of fkbp12-fk506, an immunophilin immunosuppressant complex — X-ray structure, 1995 (PDB 1FKJ), downloaded from the RCSB Protein Data Bank.
Calcineurin–FKBP–FK506 — Ternary complex of a calcineurin a fragment, calcineurin b, fkbp12 and the immunosuppressant drug fk506 (tacrolimus) — X-ray structure, 1997 (PDB 1TCO), downloaded from the RCSB Protein Data Bank.
RIPK1 kinase with inhibitor — Crystal structure of rip1 kinase with a benzo[b][1,4]oxazepin-4-one — X-ray structure, 2016 (PDB 5HX6), downloaded from the RCSB Protein Data Bank.
BTK kinase — The 1.6 a crystal structure of human bruton's tyrosine kinase bound to a pyrrolopyrimidine-containing compound — X-ray structure, 2010 (PDB 3GEN), downloaded from the RCSB Protein Data Bank.
BRAF V600E with dabrafenib — B-raf kinase v600e oncogenic mutant in complex with dabrafenib — X-ray structure, 2015 (PDB 4XV2), downloaded from the RCSB Protein Data Bank.
BTK with ibrutinib — Btk1 cocrystallized with ibrutinib — X-ray structure, 2017 (PDB 5P9J), downloaded from the RCSB Protein Data Bank.
CDK6 with palbociclib — The x-ray co-crystal structure of human cdk6 and palbociclib. — X-ray structure, 2016 (PDB 5L2I), downloaded from the RCSB Protein Data Bank.
CDK6 — X-ray structure of human cdk6-vcyclin in complex with the inhibitor pd0332991 — X-ray structure, 2006 (PDB 2EUF), downloaded from the RCSB Protein Data Bank.
CDK2 with staurosporine — Human cyclin dependent kinase 2 complexed with the inhibitor staurosporine — X-ray structure, 1997 (PDB 1AQ1), downloaded from the RCSB Protein Data Bank.
PARP1 — Structure of the catalytic domain of parp1 in complex with olaparib — X-ray structure, 2021 (PDB 7KK4), downloaded from the RCSB Protein Data Bank.
PARP — Crystal structure of constitutively active parp-1 — X-ray structure, 2016 (PDB 5DS3), downloaded from the RCSB Protein Data Bank.
SIRT1 with activator — Sirt1/activator/substrate complex — X-ray structure, 2015 (PDB 4ZZJ), downloaded from the RCSB Protein Data Bank.
BCL-2 with ABT-199 — Bcl_2-navitoclax (abt-263) complex — X-ray structure, 2013 (PDB 4LVT), downloaded from the RCSB Protein Data Bank.
BCL-2 with inhibitor — Solution structure of the anti-apoptotic protein bcl-2 in complex with an acyl-sulfonamide-based ligand — NMR structure, 2007 (PDB 2O2F), downloaded from the RCSB Protein Data Bank.
BCL-xL with Bak peptide — Structure of bcl-xl/bak peptide complex, nmr, minimized average structure — NMR structure, 1997 (PDB 1BXL), downloaded from the RCSB Protein Data Bank.
KRAS (GDP) — Crystal structure of gdp-bound human kras — X-ray structure, 2014 (PDB 4OBE), downloaded from the RCSB Protein Data Bank.
KRAS G12C — Crystal structure of kras g12d (gppcp) in complex with bi 2852 — X-ray structure, 2019 (PDB 6GJ8), downloaded from the RCSB Protein Data Bank.
KRAS (GDP-bound) — Crystal structure of k-ras wt, gdp-bound — X-ray structure, 2013 (PDB 4LPK), downloaded from the RCSB Protein Data Bank.
AChE with donepezil — Three dimensional structure of the anti-alzheimer drug, e2020 (aricept), complexed with its target acetylcholinesterase — X-ray structure, 1999 (PDB 1EVE), downloaded from the RCSB Protein Data Bank.
AChE with tacrine — Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase — X-ray structure, 1994 (PDB 1ACJ), downloaded from the RCSB Protein Data Bank.
AChE with huperzine A — Structure of acetylcholinesterase complex with (+)-huperzine a at 2.1a resolution — X-ray structure, 2002 (PDB 1GPK), downloaded from the RCSB Protein Data Bank.
COX-2 with rofecoxib — The structure of vioxx bound to human cox-2 — X-ray structure, 2016 (PDB 5KIR), downloaded from the RCSB Protein Data Bank.
COX-2 with celecoxib — Structure of celecoxib bound at the cox-2 active site — X-ray structure, 2010 (PDB 3LN1), downloaded from the RCSB Protein Data Bank.
PTP1B phosphatase — Crystal structure of protein tyrosine phosphatase 1b complexed with two phosphotyrosine molecules — X-ray structure, 1998 (PDB 1PTY), downloaded from the RCSB Protein Data Bank.
Protein kinase A — Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase — X-ray structure, 1993 (PDB 2CPK), downloaded from the RCSB Protein Data Bank.
Human CDK2 — Human cyclin-dependent kinase 2 — X-ray structure, 1996 (PDB 1HCL), downloaded from the RCSB Protein Data Bank.
Estrogen receptor with diethylstilbestrol — Human estrogen receptor alpha ligand-binding domain in complex with diethylstilbestrol and a glucocorticoid receptor interacting protein … — X-ray structure, 1999 (PDB 3ERD), downloaded from the RCSB Protein Data Bank.
ER with estradiol — Estrogen receptor alpha ligand-binding domain complexed to estradiol — X-ray structure, 1998 (PDB 1A52), downloaded from the RCSB Protein Data Bank.
Androgen receptor — Crystal structure of human androgen receptor ligand binding domain in complex with testosterone — X-ray structure, 2006 (PDB 2AM9), downloaded from the RCSB Protein Data Bank.
Androgen receptor — Human androgen receptor ligand binding in complex with the ligand metribolone (r1881) — X-ray structure, 2001 (PDB 1E3G), downloaded from the RCSB Protein Data Bank.
PPARγ ligand-binding domain — Ligand-binding domain of the human peroxisome proliferator activated receptor gamma — X-ray structure, 1999 (PDB 2PRG), downloaded from the RCSB Protein Data Bank.
PPARγ with agonist — Intact ppar gamma - rxr alpha nuclear receptor complex on dna bound with rosiglitazone, 9-cis retinoic acid and ncoa2 peptide — X-ray structure, 2008 (PDB 3DZY), downloaded from the RCSB Protein Data Bank.
Vitamin D receptor — Crystal structure of the nuclear receptor for vitamin d complexed to vitamin d — X-ray structure, 2000 (PDB 1DB1), downloaded from the RCSB Protein Data Bank.
RXRα–PPARγ heterodimer — The 2.1 angstrom resolution crystal structure of the heterodimer of the human rxralpha and ppargamma ligand binding domains respectively … — X-ray structure, 2001 (PDB 1FM6), downloaded from the RCSB Protein Data Bank.
RXR–LXR heterodimer on DNA — Crystal structure of liganded hrxr-alpha/hlxr-beta heterodimer on dna — X-ray structure, 2014 (PDB 4NQA), downloaded from the RCSB Protein Data Bank.
RXR–thyroid receptor on DNA — Retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna — X-ray structure, 1997 (PDB 2NLL), downloaded from the RCSB Protein Data Bank.
Progesterone receptor — Hormone-bound human progesterone receptor ligand-binding domain — X-ray structure, 1998 (PDB 1A28), downloaded from the RCSB Protein Data Bank.
Glucocorticoid receptor — Crystal structure of the antagonist form of glucocorticoid receptor — X-ray structure, 2003 (PDB 1NHZ), downloaded from the RCSB Protein Data Bank.
Glucocorticoid receptor — Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol — X-ray structure, 2008 (PDB 3BQD), downloaded from the RCSB Protein Data Bank.
Estrogen receptor with estradiol — Wild type estrogen nuclear receptor ligand binding domain complexed with estradiol — X-ray structure, 2000 (PDB 1QKU), downloaded from the RCSB Protein Data Bank.
Progesterone receptor with ulipristal — Progesterone receptor with bound ulipristal acetate and a peptide from the co-repressor smrt — X-ray structure, 2014 (PDB 4OAR), downloaded from the RCSB Protein Data Bank.
Dihydrofolate reductase (human) — Human dihydrofolate reductase complexed with nadph and 6-([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine (sri-9439)… — X-ray structure, 2002 (PDB 1KMS), downloaded from the RCSB Protein Data Bank.
DHFR with methotrexate — Understanding the role of leu22 variants in methotrexate resistance: comparison of wild-type and leu22arg variant mouse and human dihydrf… — X-ray structure, 2005 (PDB 1U72), downloaded from the RCSB Protein Data Bank.
Tubulin with colchicine — Tubulin-colchicine complex — X-ray structure, 2014 (PDB 4O2B), downloaded from the RCSB Protein Data Bank.
Tubulin with taxane — Tubulin-combretastatin a4 complex — X-ray structure, 2017 (PDB 5LYJ), downloaded from the RCSB Protein Data Bank.
Tubulin with vinblastine — Tubulin-colchicine-vinblastine: stathmin-like domain complex — X-ray structure, 2005 (PDB 1Z2B), downloaded from the RCSB Protein Data Bank.
Tubulin–stathmin — Tubulin-vinblastine complex — X-ray structure, 2016 (PDB 5J2T), downloaded from the RCSB Protein Data Bank.
Tubulin–stathmin — Tubulin-colchicine-soblidotin: stathmin-like domain complex — X-ray structure, 2008 (PDB 3E22), downloaded from the RCSB Protein Data Bank.
HDAC8 with SAHA — Crystal structure of human hdac8 complexed with saha — X-ray structure, 2004 (PDB 1T69), downloaded from the RCSB Protein Data Bank.
HDAC2 — Structure of human hdac2 in complex with saha (vorinostat) — X-ray structure, 2013 (PDB 4LXZ), downloaded from the RCSB Protein Data Bank.
HDAC2 — Crystal structure of human hdac2 complexed with an n-(2-aminophenyl)benzamide — X-ray structure, 2010 (PDB 3MAX), downloaded from the RCSB Protein Data Bank.
BRD4–MZ1–VHL ternary (PROTAC) — The protac mz1 in complex with the second bromodomain of brd4 and pvhl:elonginc:elonginb — X-ray structure, 2017 (PDB 5T35), downloaded from the RCSB Protein Data Bank.
CRBN–DDB1 with lenalidomide — Crystal structure of ddb1-crbn-brd4(bd1) complex bound to dbet6 protac. — X-ray structure, 2018 (PDB 6BOY), downloaded from the RCSB Protein Data Bank.
Cereblon with thalidomide — Structure of the ddb1-crbn e3 ubiquitin ligase bound to thalidomide — X-ray structure, 2014 (PDB 4CI1), downloaded from the RCSB Protein Data Bank.
CRBN–lenalidomide–CK1α — Structural basis of lenalidomide induced ck1a degradation by the crl4crbn ubiquitin ligase — X-ray structure, 2016 (PDB 5FQD), downloaded from the RCSB Protein Data Bank.
Di-ubiquitin — Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (e2) — X-ray structure, 1993 (PDB 1AAR), downloaded from the RCSB Protein Data Bank.
Ubiquitin ligase RNF4 transferring ubiquitin — A complex of of rnf4-ring domain, ubev2, ubc13-ub (isopeptide crosslink) — X-ray structure, 2015 (PDB 5AIT), downloaded from the RCSB Protein Data Bank.
26S proteasome — The human 26s proteasome at 3.9 a — cryo-EM structure, 2016 (PDB 5L4G), downloaded from the RCSB Protein Data Bank.
Penicillin-binding protein — Crystal structure of pantothenate synthetase from m. tuberculosis, low occupancy of beta-alanine at the pantoate binding sites — X-ray structure, 2003 (PDB 1N2O), downloaded from the RCSB Protein Data Bank.
β-lactamase TEM-1 — Crystal structure of escherichia coli tem1 beta-lactamase at 1.8 angstroms resolution — X-ray structure, 1995 (PDB 1BTL), downloaded from the RCSB Protein Data Bank.
TEM-1 β-lactamase — Tem1 beta lactamase — X-ray structure, 2005 (PDB 1ZG4), downloaded from the RCSB Protein Data Bank.
NDM-1 metallo-β-lactamase — Crystal structure of ndm-1 bound to hydrolyzed meropenem — X-ray structure, 2012 (PDB 4EYL), downloaded from the RCSB Protein Data Bank.
Thrombin with hirudin — Crystallographic analysis at 3.0-angstroms resolution of the binding to human thrombin of four active site-directed inhibitors — X-ray structure, 1994 (PDB 1DWC), downloaded from the RCSB Protein Data Bank.
Factor Xa — Coagulation factor xa-trypsin chimera inhibited with d-phe-pro-arg-chloromethylketone — X-ray structure, 1998 (PDB 1FXY), downloaded from the RCSB Protein Data Bank.
Factor Xa with apixaban — Factor xa in complex with the inhibitor apixaban (bms-562247) aka 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-4,5,6,7-tet… — X-ray structure, 2007 (PDB 2P16), downloaded from the RCSB Protein Data Bank.
Neuraminidase — Influenza virus b/beijing/1/87 neuraminidase complexed with zanamivir — X-ray structure, 1999 (PDB 1A4G), downloaded from the RCSB Protein Data Bank.
T4 lysozyme — T4 lysozyme l99a with benzene bound — X-ray structure, 2015 (PDB 4W52), downloaded from the RCSB Protein Data Bank.
Chloramphenicol acetyltransferase — Refined crystal structure of type iii chloramphenicol acetyltransferase at 1.75 angstroms resolution — X-ray structure, 1990 (PDB 3CLA), downloaded from the RCSB Protein Data Bank.
Muconate enzyme — Structure of muconate lactonizing enzyme at 1.85 angstroms resolution — X-ray structure, 1996 (PDB 1MUC), downloaded from the RCSB Protein Data Bank.
Insulin — Human insulin — X-ray structure, 2010 (PDB 3I40), downloaded from the RCSB Protein Data Bank.
Insulin glargine-like — Human insulin — X-ray structure, 2013 (PDB 4F1C), downloaded from the RCSB Protein Data Bank.
Insulin receptor with insulin — Insulin receptor ectodomain construct comprising domains l1-cr in complex with human insulin, alpha-ct peptide(704-719) and fab 83-7 — X-ray structure, 2013 (PDB 3W11), downloaded from the RCSB Protein Data Bank.
Insulin receptor (full) — Cryo-em structure of full-length insulin receptor bound to 4 insulin. 3d refinement was focused on the extracellular region. — cryo-EM structure, 2019 (PDB 6PXV), downloaded from the RCSB Protein Data Bank.
Hsp90–Cdc37–Cdk4 complex — Atomic cryoem structure of hsp90-cdc37-cdk4 complex — cryo-EM structure, 2016 (PDB 5FWL), downloaded from the RCSB Protein Data Bank.
Autophagy protease ATG4B — The crystal structure of human atg4b — X-ray structure, 2005 (PDB 2CY7), downloaded from the RCSB Protein Data Bank.
Cellobiohydrolase I (cellulase) — The three-dimensional crystal structure of the catalytic core of cellobiohydrolase i from trichoderma reesei — X-ray structure, 1994 (PDB 1CEL), downloaded from the RCSB Protein Data Bank.
Coagulation factor IXa — Human coagulation factor ixa in complex with p-amino benzamidine — X-ray structure, 1999 (PDB 1RFN), downloaded from the RCSB Protein Data Bank.
Retinoic acid receptor γ — Ligand-binding domain of the human retinoic acid receptor gamma bound to all-trans retinoic acid — X-ray structure, 1997 (PDB 2LBD), downloaded from the RCSB Protein Data Bank.
Thyroid receptor β with agonist — Crystal structure of human tr beta ligand-binding domain complexed with a potent subtype-selective thyromimetic — X-ray structure, 2003 (PDB 1N46), downloaded from the RCSB Protein Data Bank.
Thyroid receptor β with GC-24 — Crystal structure of human thyroid hormone receptor beta lbd in complex with specific agonist gc-24 — X-ray structure, 2004 (PDB 1Q4X), downloaded from the RCSB Protein Data Bank.