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Human proteins (AlphaFold) · Antimicrobial & innate defence: 80 3D models

DNA, RNA, nucleic-acid drugs, gene editing, proteins and 300+ real PDB structures (real sizes 1–100 nm). Each one is a ready-made 3D model you can turn, recolour and place in a figure — open BioDioRama and type its name in the Library search.

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Defensin beta 4A (DEFB4A; DEFB4B) — Defensin beta 4A — human protein (gene DEFB4A; DEFB4B, 64 amino acids, UniProt O15263). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Histone H2B type 1-K (H2BC12) — Histone H2B type 1-K — human protein (gene H2BC12, 126 amino acids, UniProt O60814). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Lysozyme-like protein 6 (LYZL6) — Lysozyme-like protein 6 — human protein (gene LYZL6, 148 amino acids, UniProt O75951). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Eppin (EPPIN) — Eppin — human protein (gene EPPIN, 133 amino acids, UniProt O95925). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Histone H2B type 1-J (H2BC11) — Histone H2B type 1-J — human protein (gene H2BC11, 126 amino acids, UniProt P06899). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Chromogranin-A (CHGA) — Chromogranin-A — human protein (gene CHGA, 457 amino acids, UniProt P10645). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Eosinophil cationic protein (RNASE3) — Eosinophil cationic protein — human protein (gene RNASE3, 160 amino acids, UniProt P12724). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Defensin alpha 4 (DEFA4) — Defensin alpha 4 — human protein (gene DEFA4, 97 amino acids, UniProt P12838). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Histatin-1 (HTN1) — Histatin-1 — human protein (gene HTN1, 57 amino acids, UniProt P15515). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Azurocidin (AZU1) — Azurocidin — human protein (gene AZU1, 251 amino acids, UniProt P20160). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Lactoperoxidase (LPO) — Lactoperoxidase — human protein (gene LPO, 712 amino acids, UniProt P22079). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Granulysin (GNLY) — Granulysin — human protein (gene GNLY, 145 amino acids, UniProt P22749). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ribonuclease 4 (RNASE4) — Ribonuclease 4 — human protein (gene RNASE4, 147 amino acids, UniProt P34096). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Small proline-rich protein 2A (SPRR2A) — Small proline-rich protein 2A — human protein (gene SPRR2A, 72 amino acids, UniProt P35326). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Matrin-3 (MATR3) — Matrin-3 — human protein (gene MATR3, 847 amino acids, UniProt P43243). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Cathelicidin antimicrobial peptide (CAMP) — Cathelicidin antimicrobial peptide — human protein (gene CAMP, 170 amino acids, UniProt P49913). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Pancreatic secretory granule membrane major glycoprotein GP2 (GP2) — Pancreatic secretory granule membrane major glycoprotein GP2 — human protein (gene GP2, 537 amino acids, UniProt P55259). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Double-stranded RNA-specific adenosine deaminase (ADAR) — Double-stranded RNA-specific adenosine deaminase — human protein (gene ADAR, 1226 amino acids, UniProt P55265). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Histone H2B type F-S (H2BC12L) — Histone H2B type F-S — human protein (gene H2BC12L, 126 amino acids, UniProt P57053). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transmembrane protein 33 (TMEM33) — Transmembrane protein 33 — human protein (gene TMEM33, 247 amino acids, UniProt P57088). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Gasdermin-D (GSDMD) — Gasdermin-D — human protein (gene GSDMD, 484 amino acids, UniProt P57764). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Toll/interleukin-1 receptor domain-containing adapter protein (TIRAP) — Toll/interleukin-1 receptor domain-containing adapter protein — human protein (gene TIRAP, 221 amino acids, UniProt P58753). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
NACHT, LRR and PYD domains-containing protein 6 (NLRP6) — NACHT, LRR and PYD domains-containing protein 6 — human protein (gene NLRP6, 892 amino acids, UniProt P59044). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Neutrophil defensin 1 (DEFA1; DEFA1B) — Neutrophil defensin 1 — human protein (gene DEFA1; DEFA1B, 94 amino acids, UniProt P59665). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Neutrophil defensin 3 (DEFA3) — Neutrophil defensin 3 — human protein (gene DEFA3, 94 amino acids, UniProt P59666). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4) — Leukocyte immunoglobulin-like receptor subfamily A member 4 — human protein (gene LILRA4, 499 amino acids, UniProt P59901). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Beta-defensin 1 (DEFB1) — Beta-defensin 1 — human protein (gene DEFB1, 68 amino acids, UniProt P60022). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Reactive oxygen species modulator 1 (ROMO1) — Reactive oxygen species modulator 1 — human protein (gene ROMO1, 79 amino acids, UniProt P60602). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Lysozyme C (LYZ) — Lysozyme C — human protein (gene LYZ, 148 amino acids, UniProt P61626). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Histone H2B type 1-C/E/F/G/I (H2BC4; H2BC6; H2BC7; H2BC8; H2BC10) — Histone H2B type 1-C/E/F/G/I — human protein (gene H2BC4; H2BC6; H2BC7; H2BC8; H2BC10, 126 amino acids, UniProt P62807). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Arginase-2, mitochondrial (ARG2) — Arginase-2, mitochondrial — human protein (gene ARG2, 354 amino acids, UniProt P78540). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Double-stranded RNA-specific editase 1 (ADARB1) — Double-stranded RNA-specific editase 1 — human protein (gene ADARB1, 741 amino acids, UniProt P78563). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Interferon-induced 35 kDa protein (IFI35) — Interferon-induced 35 kDa protein — human protein (gene IFI35, 286 amino acids, UniProt P80217). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Protein S100-A12 (S100A12) — Protein S100-A12 — human protein (gene S100A12, 92 amino acids, UniProt P80511). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Beta-defensin 103 (DEFB103A; DEFB103B) — Beta-defensin 103 — human protein (gene DEFB103A; DEFB103B, 67 amino acids, UniProt P81534). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Defensin alpha 5 (DEFA5) — Defensin alpha 5 — human protein (gene DEFA5, 94 amino acids, UniProt Q01523). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Defensin-6 (DEFA6) — Defensin-6 — human protein (gene DEFA6, 100 amino acids, UniProt Q01524). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Interferon-induced transmembrane protein 3 (IFITM3) — Interferon-induced transmembrane protein 3 — human protein (gene IFITM3, 133 amino acids, UniProt Q01628). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Interferon-induced transmembrane protein 2 (IFITM2) — Interferon-induced transmembrane protein 2 — human protein (gene IFITM2, 132 amino acids, UniProt Q01629). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
AT-rich interactive domain-containing protein 5A (ARID5A) — AT-rich interactive domain-containing protein 5A — human protein (gene ARID5A, 594 amino acids, UniProt Q03989). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
2-5A-dependent ribonuclease (RNASEL) — 2-5A-dependent ribonuclease — human protein (gene RNASEL, 741 amino acids, UniProt Q05823). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Regenerating islet-derived protein 3-alpha (REG3A) — Regenerating islet-derived protein 3-alpha — human protein (gene REG3A, 175 amino acids, UniProt Q06141). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Protein spire homolog 1 (SPIRE1) — Protein spire homolog 1 — human protein (gene SPIRE1, 756 amino acids, UniProt Q08AE8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Bone marrow stromal antigen 2 (BST2) — Bone marrow stromal antigen 2 — human protein (gene BST2, 180 amino acids, UniProt Q10589). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tripartite motif-containing protein 26 (TRIM26) — Tripartite motif-containing protein 26 — human protein (gene TRIM26, 539 amino acids, UniProt Q12899). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Natural killer cells antigen CD94 (KLRD1) — Natural killer cells antigen CD94 — human protein (gene KLRD1, 179 amino acids, UniProt Q13241). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ras GTPase-activating protein-binding protein 1 (G3BP1) — Ras GTPase-activating protein-binding protein 1 — human protein (gene G3BP1, 466 amino acids, UniProt Q13283). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
N-myc-interactor (NMI) — N-myc-interactor — human protein (gene NMI, 307 amino acids, UniProt Q13287). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Interferon-induced protein with tetratricopeptide repeats 5 (IFIT5) — Interferon-induced protein with tetratricopeptide repeats 5 — human protein (gene IFIT5, 482 amino acids, UniProt Q13325). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transmembrane emp24 domain-containing protein 1 (TMED1) — Transmembrane emp24 domain-containing protein 1 — human protein (gene TMED1, 227 amino acids, UniProt Q13445). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Serine incorporator 3 (SERINC3) — Serine incorporator 3 — human protein (gene SERINC3, 473 amino acids, UniProt Q13530). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Interferon regulatory factor 5 (IRF5) — Interferon regulatory factor 5 — human protein (gene IRF5, 498 amino acids, UniProt Q13568). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tripartite motif-containing protein 29 (TRIM29) — Tripartite motif-containing protein 29 — human protein (gene TRIM29, 588 amino acids, UniProt Q14134). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tripartite motif-containing protein 14 (TRIM14) — Tripartite motif-containing protein 14 — human protein (gene TRIM14, 442 amino acids, UniProt Q14142). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
MORC family CW-type zinc finger protein 3 (MORC3) — MORC family CW-type zinc finger protein 3 — human protein (gene MORC3, 939 amino acids, UniProt Q14149). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tubulin--tyrosine ligase-like protein 12 (TTLL12) — Tubulin--tyrosine ligase-like protein 12 — human protein (gene TTLL12, 644 amino acids, UniProt Q14166). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Interferon regulatory factor 3 (IRF3) — Interferon regulatory factor 3 — human protein (gene IRF3, 427 amino acids, UniProt Q14653). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Poly(rC)-binding protein 2 (PCBP2) — Poly(rC)-binding protein 2 — human protein (gene PCBP2, 365 amino acids, UniProt Q15366). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Toll-like receptor 1 (TLR1) — Toll-like receptor 1 — human protein (gene TLR1, 786 amino acids, UniProt Q15399). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
2'-5'-oligoadenylate synthase-like protein (OASL) — 2'-5'-oligoadenylate synthase-like protein — human protein (gene OASL, 514 amino acids, UniProt Q15646). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
UDP-N-acetylhexosamine pyrophosphorylase (UAP1) — UDP-N-acetylhexosamine pyrophosphorylase — human protein (gene UAP1, 522 amino acids, UniProt Q16222). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Solute carrier family 15 member 2 (SLC15A2) — Solute carrier family 15 member 2 — human protein (gene SLC15A2, 729 amino acids, UniProt Q16348). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Histone H2B type 2-E (H2BC21) — Histone H2B type 2-E — human protein (gene H2BC21, 126 amino acids, UniProt Q16778). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Macrophage-expressed gene 1 protein (MPEG1) — Macrophage-expressed gene 1 protein — human protein (gene MPEG1, 716 amino acids, UniProt Q2M385). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Beta-defensin 114 (DEFB114) — Beta-defensin 114 — human protein (gene DEFB114, 69 amino acids, UniProt Q30KQ6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Innate immunity activator protein (INAVA) — Innate immunity activator protein — human protein (gene INAVA, 663 amino acids, UniProt Q3KP66). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Protein mono-ADP-ribosyltransferase PARP14 (PARP14) — Protein mono-ADP-ribosyltransferase PARP14 — human protein (gene PARP14, 1801 amino acids, UniProt Q460N5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Akirin-2 (AKIRIN2) — Akirin-2 — human protein (gene AKIRIN2, 203 amino acids, UniProt Q53H80). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Coiled-coil domain-containing protein 92 (CCDC92) — Coiled-coil domain-containing protein 92 — human protein (gene CCDC92, 331 amino acids, UniProt Q53HC0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Pyrin domain-containing protein 2 (PYDC2) — Pyrin domain-containing protein 2 — human protein (gene PYDC2, 97 amino acids, UniProt Q56P42). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Sterile alpha motif domain-containing protein 9 (SAMD9) — Sterile alpha motif domain-containing protein 9 — human protein (gene SAMD9, 1589 amino acids, UniProt Q5K651). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
ATP-binding cassette sub-family C member 10 (ABCC10) — ATP-binding cassette sub-family C member 10 — human protein (gene ABCC10, 1492 amino acids, UniProt Q5T3U5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Late cornified envelope protein 3C (LCE3C) — Late cornified envelope protein 3C — human protein (gene LCE3C, 94 amino acids, UniProt Q5T5A8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Late cornified envelope protein 3A (LCE3A) — Late cornified envelope protein 3A — human protein (gene LCE3A, 89 amino acids, UniProt Q5TA76). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Late cornified envelope protein 3B (LCE3B) — Late cornified envelope protein 3B — human protein (gene LCE3B, 95 amino acids, UniProt Q5TA77). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Interleukin-23 receptor (IL23R) — Interleukin-23 receptor — human protein (gene IL23R, 629 amino acids, UniProt Q5VWK5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
C-type lectin domain family 6 member A (CLEC6A) — C-type lectin domain family 6 member A — human protein (gene CLEC6A, 209 amino acids, UniProt Q6EIG7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
DNA dC->dU-editing enzyme APOBEC-3H (APOBEC3H) — DNA dC->dU-editing enzyme APOBEC-3H — human protein (gene APOBEC3H, 200 amino acids, UniProt Q6NTF7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tumor necrosis factor alpha-induced protein 8-like protein 2 (TNFAIP8L2) — Tumor necrosis factor alpha-induced protein 8-like protein 2 — human protein (gene TNFAIP8L2, 184 amino acids, UniProt Q6P589). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase TRIM65 (TRIM65) — E3 ubiquitin-protein ligase TRIM65 — human protein (gene TRIM65, 517 amino acids, UniProt Q6PJ69). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).