Library › DNA & Proteins › Human proteins (AlphaFold) · cGAS-STING & innate DNA sensing

Human proteins (AlphaFold) · cGAS-STING & innate DNA sensing: 50 3D models

DNA, RNA, nucleic-acid drugs, gene editing, proteins and 300+ real PDB structures (real sizes 1–100 nm). Each one is a ready-made 3D model you can turn, recolour and place in a figure — open BioDiorama and type its name in the Library search.

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Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) — Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 — human protein (gene ENPP1, 925 amino acids, UniProt P22413). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
UBX domain-containing protein 1 (UBXN1) — UBX domain-containing protein 1 — human protein (gene UBXN1, 297 amino acids, UniProt Q04323). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) — Inhibitor of nuclear factor kappa-B kinase subunit epsilon — human protein (gene IKBKE, 716 amino acids, UniProt Q14164). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) — Leucine-rich repeat flightless-interacting protein 1 — human protein (gene LRRFIP1, 808 amino acids, UniProt Q32MZ4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Coiled-coil domain-containing protein 50 (CCDC50) — Coiled-coil domain-containing protein 50 — human protein (gene CCDC50, 306 amino acids, UniProt Q8IVM0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Interferon regulatory factor 7 (IRF7) — Interferon regulatory factor 7 — human protein (gene IRF7, 503 amino acids, UniProt Q92985). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase RNF185 (RNF185) — E3 ubiquitin-protein ligase RNF185 — human protein (gene RNF185, 192 amino acids, UniProt Q96GF1). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Three prime repair exonuclease 2 (TREX2) — Three prime repair exonuclease 2 — human protein (gene TREX2, 236 amino acids, UniProt Q9BQ50). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase TRIM56 (TRIM56) — E3 ubiquitin-protein ligase TRIM56 — human protein (gene TRIM56, 755 amino acids, UniProt Q9BRZ2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Toll-interacting protein (TOLLIP) — Toll-interacting protein — human protein (gene TOLLIP, 274 amino acids, UniProt Q9H0E2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
STING ER exit protein (STEEP1) — STING ER exit protein — human protein (gene STEEP1, 222 amino acids, UniProt Q9H5V9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Three-prime repair exonuclease 1 (TREX1) — Three-prime repair exonuclease 1 — human protein (gene TREX1, 314 amino acids, UniProt Q9NSU2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
DNA-directed RNA polymerase III subunit RPC2 (POLR3B) — DNA-directed RNA polymerase III subunit RPC2 — human protein (gene POLR3B, 1133 amino acids, UniProt Q9NW08). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) — Insulin-like growth factor 2 mRNA-binding protein 1 — human protein (gene IGF2BP1, 577 amino acids, UniProt Q9NZI8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Serine/threonine-protein kinase TBK1 (TBK1) — Serine/threonine-protein kinase TBK1 — human protein (gene TBK1, 729 amino acids, UniProt Q9UHD2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase AMFR (AMFR) — E3 ubiquitin-protein ligase AMFR — human protein (gene AMFR, 643 amino acids, UniProt Q9UKV5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Sorting nexin-8 (SNX8) — Sorting nexin-8 — human protein (gene SNX8, 465 amino acids, UniProt Q9Y5X2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Signal transducer and activator of transcription 1-alpha/beta (STAT1) — Signal transducer and activator of transcription 1-alpha/beta — human protein (gene STAT1, 750 amino acids, UniProt P42224). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Signal transducer and activator of transcription 2 (STAT2) — Signal transducer and activator of transcription 2 — human protein (gene STAT2, 851 amino acids, UniProt P52630). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Interferon regulatory factor 9 (IRF9) — Interferon regulatory factor 9 — human protein (gene IRF9, 393 amino acids, UniProt Q00978). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transcription factor p65 (RELA) — Transcription factor p65 — human protein (gene RELA, 551 amino acids, UniProt Q04206). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Mitochondrial antiviral-signaling protein (MAVS) — Mitochondrial antiviral-signaling protein — human protein (gene MAVS, 540 amino acids, UniProt Q7Z434). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Interferon-induced helicase C domain-containing protein 1 (IFIH1) — Interferon-induced helicase C domain-containing protein 1 — human protein (gene IFIH1, 1025 amino acids, UniProt Q9BYX4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1) — Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 — human protein (gene SAMHD1, 626 amino acids, UniProt Q9Y3Z3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
TNF receptor-associated factor 6 (TRAF6) — TNF receptor-associated factor 6 — human protein (gene TRAF6, 522 amino acids, UniProt Q9Y4K3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
2'-5'-oligoadenylate synthase 3 (OAS3) — 2'-5'-oligoadenylate synthase 3 — human protein (gene OAS3, 1087 amino acids, UniProt Q9Y6K5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
NF-kappa-B essential modulator (IKBKG) — NF-kappa-B essential modulator — human protein (gene IKBKG, 419 amino acids, UniProt Q9Y6K9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3) — Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 — human protein (gene ENPP3, 875 amino acids, UniProt O14638). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Barrier-to-autointegration factor (BANF1) — Barrier-to-autointegration factor — human protein (gene BANF1, 89 amino acids, UniProt O75531). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Protein transport protein Sec24A (SEC24A) — Protein transport protein Sec24A — human protein (gene SEC24A, 1093 amino acids, UniProt O95486). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Protein transport protein Sec24C (SEC24C) — Protein transport protein Sec24C — human protein (gene SEC24C, 1094 amino acids, UniProt P53992). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) — TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 — human protein (gene TAB1, 504 amino acids, UniProt Q15750). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Alanine--tRNA ligase, mitochondrial (AARS2) — Alanine--tRNA ligase, mitochondrial — human protein (gene AARS2, 985 amino acids, UniProt Q5JTZ9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Lysophospholipase-like protein 1 (LYPLAL1) — Lysophospholipase-like protein 1 — human protein (gene LYPLAL1, 237 amino acids, UniProt Q5VWZ2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A) — Cyclic GMP-AMP phosphodiesterase SMPDL3A — human protein (gene SMPDL3A, 453 amino acids, UniProt Q92484). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Histone acetyltransferase KAT2A (KAT2A) — Histone acetyltransferase KAT2A — human protein (gene KAT2A, 837 amino acids, UniProt Q92830). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Stathmin-2 (STMN2) — Stathmin-2 — human protein (gene STMN2, 179 amino acids, UniProt Q93045). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transmembrane protein 203 (TMEM203) — Transmembrane protein 203 — human protein (gene TMEM203, 136 amino acids, UniProt Q969S6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) — Mitochondrial ubiquitin ligase activator of NFKB 1 — human protein (gene MUL1, 352 amino acids, UniProt Q969V5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Aurora kinase B (AURKB) — Aurora kinase B — human protein (gene AURKB, 344 amino acids, UniProt Q96GD4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transmembrane protein 43 (TMEM43) — Transmembrane protein 43 — human protein (gene TMEM43, 400 amino acids, UniProt Q9BTV4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transmembrane protein 120A (TMEM120A) — Transmembrane protein 120A — human protein (gene TMEM120A, 343 amino acids, UniProt Q9BXJ8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
RING finger protein 39 (RNF39) — RING finger protein 39 — human protein (gene RNF39, 420 amino acids, UniProt Q9H2S5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Palmitoyltransferase ZDHHC18 (ZDHHC18) — Palmitoyltransferase ZDHHC18 — human protein (gene ZDHHC18, 388 amino acids, UniProt Q9NUE0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) — E3 ubiquitin-protein ligase MARCHF5 — human protein (gene MARCHF5, 278 amino acids, UniProt Q9NX47). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase TRIM10 (TRIM10) — E3 ubiquitin-protein ligase TRIM10 — human protein (gene TRIM10, 481 amino acids, UniProt Q9UDY6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ISG15--protein ligase HERC5 (HERC5) — E3 ISG15--protein ligase HERC5 — human protein (gene HERC5, 1024 amino acids, UniProt Q9UII4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ubl carboxyl-terminal hydrolase 18 (USP18) — Ubl carboxyl-terminal hydrolase 18 — human protein (gene USP18, 372 amino acids, UniProt Q9UMW8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE) — 1-phosphatidylinositol 3-phosphate 5-kinase — human protein (gene PIKFYVE, 2098 amino acids, UniProt Q9Y2I7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Small COPII coat GTPase SAR1B (SAR1B) — Small COPII coat GTPase SAR1B — human protein (gene SAR1B, 198 amino acids, UniProt Q9Y6B6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).