Library › DNA & Proteins › Human proteins (AlphaFold) · Immune checkpoints & co-stimulation

Human proteins (AlphaFold) · Immune checkpoints & co-stimulation: 62 3D models

DNA, RNA, nucleic-acid drugs, gene editing, proteins and 300+ real PDB structures (real sizes 1–100 nm). Each one is a ready-made 3D model you can turn, recolour and place in a figure — open BioDiorama and type its name in the Library search.

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Tryptophan 2,3-dioxygenase (TDO2) — Tryptophan 2,3-dioxygenase — human protein (gene TDO2, 406 amino acids, UniProt P48775). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA) — Tyrosine-protein phosphatase non-receptor type substrate 1 — human protein (gene SIRPA, 504 amino acids, UniProt P78324). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) — T-cell immunoreceptor with Ig and ITIM domains — human protein (gene TIGIT, 244 amino acids, UniProt Q495A1). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
CD276 antigen (CD276) — CD276 antigen — human protein (gene CD276, 534 amino acids, UniProt Q5ZPR3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Sialic acid-binding Ig-like lectin 15 (SIGLEC15) — Sialic acid-binding Ig-like lectin 15 — human protein (gene SIGLEC15, 328 amino acids, UniProt Q6ZMC9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Indoleamine 2,3-dioxygenase 2 (IDO2) — Indoleamine 2,3-dioxygenase 2 — human protein (gene IDO2, 407 amino acids, UniProt Q6ZQW0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
B- and T-lymphocyte attenuator (BTLA) — B- and T-lymphocyte attenuator — human protein (gene BTLA, 289 amino acids, UniProt Q7Z6A9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
V-set domain-containing T-cell activation inhibitor 1 (VTCN1) — V-set domain-containing T-cell activation inhibitor 1 — human protein (gene VTCN1, 282 amino acids, UniProt Q7Z7D3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2) — Leukocyte immunoglobulin-like receptor subfamily A member 2 — human protein (gene LILRA2, 483 amino acids, UniProt Q8N149). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) — Leukocyte immunoglobulin-like receptor subfamily B member 2 — human protein (gene LILRB2, 597 amino acids, UniProt Q8N423). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) — Leukocyte immunoglobulin-like receptor subfamily B member 4 — human protein (gene LILRB4, 448 amino acids, UniProt Q8NHJ6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) — Leukocyte immunoglobulin-like receptor subfamily B member 1 — human protein (gene LILRB1, 650 amino acids, UniProt Q8NHL6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Hepatitis A virus cellular receptor 2 (HAVCR2) — Hepatitis A virus cellular receptor 2 — human protein (gene HAVCR2, 301 amino acids, UniProt Q8TDQ0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Nectin-2 (NECTIN2) — Nectin-2 — human protein (gene NECTIN2, 538 amino acids, UniProt Q92692). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) — Tumor necrosis factor receptor superfamily member 14 — human protein (gene TNFRSF14, 283 amino acids, UniProt Q92956). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Sialic acid-binding Ig-like lectin 10 (SIGLEC10) — Sialic acid-binding Ig-like lectin 10 — human protein (gene SIGLEC10, 697 amino acids, UniProt Q96LC7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Nectin-4 (NECTIN4) — Nectin-4 — human protein (gene NECTIN4, 510 amino acids, UniProt Q96NY8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Programmed cell death 1 ligand 2 (PDCD1LG2) — Programmed cell death 1 ligand 2 — human protein (gene PDCD1LG2, 273 amino acids, UniProt Q9BQ51). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR) — V-type immunoglobulin domain-containing suppressor of T-cell activation — human protein (gene VSIR, 311 amino acids, UniProt Q9H7M9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Nectin-3 (NECTIN3) — Nectin-3 — human protein (gene NECTIN3, 549 amino acids, UniProt Q9NQS3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Programmed cell death 1 ligand 1 (CD274) — Programmed cell death 1 ligand 1 — human protein (gene CD274, 290 amino acids, UniProt Q9NZQ7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Signal-regulatory protein gamma (SIRPG) — Signal-regulatory protein gamma — human protein (gene SIRPG, 387 amino acids, UniProt Q9P1W8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Sialic acid-binding Ig-like lectin 7 (SIGLEC7) — Sialic acid-binding Ig-like lectin 7 — human protein (gene SIGLEC7, 467 amino acids, UniProt Q9Y286). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Sialic acid-binding Ig-like lectin 9 (SIGLEC9) — Sialic acid-binding Ig-like lectin 9 — human protein (gene SIGLEC9, 463 amino acids, UniProt Q9Y336). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Inducible T-cell costimulator (ICOS) — Inducible T-cell costimulator — human protein (gene ICOS, 199 amino acids, UniProt Q9Y6W8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
CD48 antigen (CD48) — CD48 antigen — human protein (gene CD48, 243 amino acids, UniProt P09326). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Cell adhesion molecule CEACAM1 (CEACAM1) — Cell adhesion molecule CEACAM1 — human protein (gene CEACAM1, 526 amino acids, UniProt P13688). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Lymphocyte function-associated antigen 3 (CD58) — Lymphocyte function-associated antigen 3 — human protein (gene CD58, 250 amino acids, UniProt P19256). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
CD70 antigen (CD70) — CD70 antigen — human protein (gene CD70, 193 amino acids, UniProt P32970). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
OX-2 membrane glycoprotein (CD200) — OX-2 membrane glycoprotein — human protein (gene CD200, 278 amino acids, UniProt P41217). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tumor necrosis factor receptor superfamily member 9 (TNFRSF9) — Tumor necrosis factor receptor superfamily member 9 — human protein (gene TNFRSF9, 255 amino acids, UniProt Q07011). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Fibrinogen-like protein 1 (FGL1) — Fibrinogen-like protein 1 — human protein (gene FGL1, 312 amino acids, UniProt Q08830). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) — Leukocyte-associated immunoglobulin-like receptor 1 — human protein (gene LAIR1, 287 amino acids, UniProt Q6GTX8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Cell surface glycoprotein CD200 receptor 1 (CD200R1) — Cell surface glycoprotein CD200 receptor 1 — human protein (gene CD200R1, 348 amino acids, UniProt Q8TD46). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
CMRF35-like molecule 1 (CD300LF) — CMRF35-like molecule 1 — human protein (gene CD300LF, 290 amino acids, UniProt Q8TDQ1). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2) — Transmembrane and immunoglobulin domain-containing protein 2 — human protein (gene TMIGD2, 282 amino acids, UniProt Q96BF3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
SLAM family member 6 (SLAMF6) — SLAM family member 6 — human protein (gene SLAMF6, 332 amino acids, UniProt Q96DU3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Natural killer cell receptor 2B4 (CD244) — Natural killer cell receptor 2B4 — human protein (gene CD244, 370 amino acids, UniProt Q9BZW8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
SLAM family member 7 (SLAMF7) — SLAM family member 7 — human protein (gene SLAMF7, 335 amino acids, UniProt Q9NQ25). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
CMRF35-like molecule 8 (CD300A) — CMRF35-like molecule 8 — human protein (gene CD300A, 299 amino acids, UniProt Q9UGN4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
HERV-H LTR-associating protein 2 (HHLA2) — HERV-H LTR-associating protein 2 — human protein (gene HHLA2, 414 amino acids, UniProt Q9UM44). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tumor necrosis factor ligand superfamily member 18 (TNFSF18) — Tumor necrosis factor ligand superfamily member 18 — human protein (gene TNFSF18, 177 amino acids, UniProt Q9UNG2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18) — Tumor necrosis factor receptor superfamily member 18 — human protein (gene TNFRSF18, 241 amino acids, UniProt Q9Y5U5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
5'-nucleotidase (NT5E) — 5'-nucleotidase — human protein (gene NT5E, 574 amino acids, UniProt P21589). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) — Ectonucleoside triphosphate diphosphohydrolase 1 — human protein (gene ENTPD1, 510 amino acids, UniProt P49961). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) — 3',5'-cyclic-AMP phosphodiesterase 4D — human protein (gene PDE4D, 809 amino acids, UniProt Q08499). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Interleukin-10 receptor subunit alpha (IL10RA) — Interleukin-10 receptor subunit alpha — human protein (gene IL10RA, 578 amino acids, UniProt Q13651). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
MHC class I polypeptide-related sequence B (MICB) — MHC class I polypeptide-related sequence B — human protein (gene MICB, 383 amino acids, UniProt Q29980). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
MHC class I polypeptide-related sequence A (MICA) — MHC class I polypeptide-related sequence A — human protein (gene MICA, 383 amino acids, UniProt Q29983). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1) — Natural cytotoxicity triggering receptor 3 ligand 1 — human protein (gene NCR3LG1, 454 amino acids, UniProt Q68D85). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Hepatitis A virus cellular receptor 1 (HAVCR1) — Hepatitis A virus cellular receptor 1 — human protein (gene HAVCR1, 364 amino acids, UniProt Q96D42). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
UL16-binding protein 3 (ULBP3) — UL16-binding protein 3 — human protein (gene ULBP3, 244 amino acids, UniProt Q9BZM4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
UL16-binding protein 2 (ULBP2) — UL16-binding protein 2 — human protein (gene ULBP2, 246 amino acids, UniProt Q9BZM5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
UL16-binding protein 1 (ULBP1) — UL16-binding protein 1 — human protein (gene ULBP1, 244 amino acids, UniProt Q9BZM6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Forkhead box protein P3 (FOXP3) — Forkhead box protein P3 — human protein (gene FOXP3, 431 amino acids, UniProt Q9BZS1). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Cytokine-inducible SH2-containing protein (CISH) — Cytokine-inducible SH2-containing protein — human protein (gene CISH, 258 amino acids, UniProt Q9NSE2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Nocturnin (NOCT) — Nocturnin — human protein (gene NOCT, 431 amino acids, UniProt Q9UK39). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
CCR4-NOT transcription complex subunit 6 (CNOT6) — CCR4-NOT transcription complex subunit 6 — human protein (gene CNOT6, 557 amino acids, UniProt Q9ULM6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) — Tumor necrosis factor receptor superfamily member 25 — human protein (gene TNFRSF25, 417 amino acids, UniProt Q93038). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Major histocompatibility complex class I-related protein 1 (MR1) — Major histocompatibility complex class I-related protein 1 — human protein (gene MR1, 341 amino acids, UniProt Q95460). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) — Tumor necrosis factor receptor superfamily member 13C — human protein (gene TNFRSF13C, 184 amino acids, UniProt Q96RJ3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) — Leukocyte-associated immunoglobulin-like receptor 2 — human protein (gene LAIR2, 152 amino acids, UniProt Q6ISS4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).