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Human proteins (AlphaFold) · Ubiquitin–proteasome system: 75 3D models

DNA, RNA, nucleic-acid drugs, gene editing, proteins and 300+ real PDB structures (real sizes 1–100 nm). Each one is a ready-made 3D model you can turn, recolour and place in a figure — open BioDiorama and type its name in the Library search.

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Cullin-9 (CUL9) — Cullin-9 — human protein (gene CUL9, 2517 amino acids, UniProt Q8IWT3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
F-box/WD repeat-containing protein 8 (FBXW8) — F-box/WD repeat-containing protein 8 — human protein (gene FBXW8, 598 amino acids, UniProt Q8N3Y1). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
DDB1- and CUL4-associated factor 11 (DCAF11) — DDB1- and CUL4-associated factor 11 — human protein (gene DCAF11, 546 amino acids, UniProt Q8TEB1). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Cullin-5 (CUL5) — Cullin-5 — human protein (gene CUL5, 780 amino acids, UniProt Q93034). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Baculoviral IAP repeat-containing protein 7 (BIRC7) — Baculoviral IAP repeat-containing protein 7 — human protein (gene BIRC7, 298 amino acids, UniProt Q96CA5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
DDB1- and CUL4-associated factor 5 (DCAF5) — DDB1- and CUL4-associated factor 5 — human protein (gene DCAF5, 942 amino acids, UniProt Q96JK2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Protein cereblon (CRBN) — Protein cereblon — human protein (gene CRBN, 442 amino acids, UniProt Q96SW2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
DDB1- and CUL4-associated factor 13 (DCAF13) — DDB1- and CUL4-associated factor 13 — human protein (gene DCAF13, 445 amino acids, UniProt Q9NV06). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
RING-box protein 2 (RNF7) — RING-box protein 2 — human protein (gene RNF7, 113 amino acids, UniProt Q9UBF6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
F-box/WD repeat-containing protein 2 (FBXW2) — F-box/WD repeat-containing protein 2 — human protein (gene FBXW2, 454 amino acids, UniProt Q9UKT8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase UBR1 (UBR1) — E3 ubiquitin-protein ligase UBR1 — human protein (gene UBR1, 1749 amino acids, UniProt Q8IWV7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase UBR2 (UBR2) — E3 ubiquitin-protein ligase UBR2 — human protein (gene UBR2, 1755 amino acids, UniProt Q8IWV8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase RNF25 (RNF25) — E3 ubiquitin-protein ligase RNF25 — human protein (gene RNF25, 459 amino acids, UniProt Q96BH1). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase RNF31 (RNF31) — E3 ubiquitin-protein ligase RNF31 — human protein (gene RNF31, 1072 amino acids, UniProt Q96EP0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) — E3 ubiquitin-protein ligase NEDD4-like — human protein (gene NEDD4L, 975 amino acids, UniProt Q96PU5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase RNF126 (RNF126) — E3 ubiquitin-protein ligase RNF126 — human protein (gene RNF126, 311 amino acids, UniProt Q9BV68). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1) — NEDD4-like E3 ubiquitin-protein ligase WWP1 — human protein (gene WWP1, 922 amino acids, UniProt Q9H0M0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase TRIM33 (TRIM33) — E3 ubiquitin-protein ligase TRIM33 — human protein (gene TRIM33, 1127 amino acids, UniProt Q9UPN9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ubiquitin carboxyl-terminal hydrolase 25 (USP25) — Ubiquitin carboxyl-terminal hydrolase 25 — human protein (gene USP25, 1055 amino acids, UniProt Q9UHP3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ubiquitin carboxyl-terminal hydrolase 16 (USP16) — Ubiquitin carboxyl-terminal hydrolase 16 — human protein (gene USP16, 823 amino acids, UniProt Q9Y5T5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ubiquitin carboxyl-terminal hydrolase 9X (USP9X) — Ubiquitin carboxyl-terminal hydrolase 9X — human protein (gene USP9X, 2554 amino acids, UniProt Q93008). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
SUMO-activating enzyme subunit 1 (SAE1) — SUMO-activating enzyme subunit 1 — human protein (gene SAE1, 346 amino acids, UniProt Q9UBE0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Sentrin-specific protease 5 (SENP5) — Sentrin-specific protease 5 — human protein (gene SENP5, 755 amino acids, UniProt Q96HI0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
NEDD8-conjugating enzyme UBE2F (UBE2F) — NEDD8-conjugating enzyme UBE2F — human protein (gene UBE2F, 185 amino acids, UniProt Q969M7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ubiquitin carboxyl-terminal hydrolase 32 (USP32) — Ubiquitin carboxyl-terminal hydrolase 32 — human protein (gene USP32, 1604 amino acids, UniProt Q8NFA0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
SUMO-activating enzyme subunit 2 (UBA2) — SUMO-activating enzyme subunit 2 — human protein (gene UBA2, 640 amino acids, UniProt Q9UBT2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ubiquitin carboxyl-terminal hydrolase 15 (USP15) — Ubiquitin carboxyl-terminal hydrolase 15 — human protein (gene USP15, 981 amino acids, UniProt Q9Y4E8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
NEDD8-activating enzyme E1 catalytic subunit (UBA3) — NEDD8-activating enzyme E1 catalytic subunit — human protein (gene UBA3, 463 amino acids, UniProt Q8TBC4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
OTU domain-containing protein 5 (OTUD5) — OTU domain-containing protein 5 — human protein (gene OTUD5, 571 amino acids, UniProt Q96G74). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
COP9 signalosome complex subunit 6 (COPS6) — COP9 signalosome complex subunit 6 — human protein (gene COPS6, 327 amino acids, UniProt Q7L5N1). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome subunit beta type-4 (PSMB4) — Proteasome subunit beta type-4 — human protein (gene PSMB4, 264 amino acids, UniProt P28070). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome subunit alpha type-5 (PSMA5) — Proteasome subunit alpha type-5 — human protein (gene PSMA5, 241 amino acids, UniProt P28066). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome subunit alpha type-7 (PSMA7) — Proteasome subunit alpha type-7 — human protein (gene PSMA7, 248 amino acids, UniProt O14818). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ubiquitin carboxyl-terminal hydrolase 36 (USP36) — Ubiquitin carboxyl-terminal hydrolase 36 — human protein (gene USP36, 1123 amino acids, UniProt Q9P275). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome subunit beta type-3 (PSMB3) — Proteasome subunit beta type-3 — human protein (gene PSMB3, 205 amino acids, UniProt P49720). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome subunit beta type-1 (PSMB1) — Proteasome subunit beta type-1 — human protein (gene PSMB1, 241 amino acids, UniProt P20618). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ubiquitin carboxyl-terminal hydrolase 22 (USP22) — Ubiquitin carboxyl-terminal hydrolase 22 — human protein (gene USP22, 525 amino acids, UniProt Q9UPT9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome subunit beta type-7 (PSMB7) — Proteasome subunit beta type-7 — human protein (gene PSMB7, 277 amino acids, UniProt Q99436). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome subunit alpha type-2 (PSMA2) — Proteasome subunit alpha type-2 — human protein (gene PSMA2, 234 amino acids, UniProt P25787). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome subunit alpha type-4 (PSMA4) — Proteasome subunit alpha type-4 — human protein (gene PSMA4, 261 amino acids, UniProt P25789). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome subunit alpha type-3 (PSMA3) — Proteasome subunit alpha type-3 — human protein (gene PSMA3, 255 amino acids, UniProt P25788). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ubiquitin carboxyl-terminal hydrolase 37 (USP37) — Ubiquitin carboxyl-terminal hydrolase 37 — human protein (gene USP37, 979 amino acids, UniProt Q86T82). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome subunit beta type-2 (PSMB2) — Proteasome subunit beta type-2 — human protein (gene PSMB2, 201 amino acids, UniProt P49721). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase RING2 (RNF2) — E3 ubiquitin-protein ligase RING2 — human protein (gene RNF2, 336 amino acids, UniProt Q99496). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome subunit alpha type-6 (PSMA6) — Proteasome subunit alpha type-6 — human protein (gene PSMA6, 246 amino acids, UniProt P60900). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1) — Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 — human protein (gene MAGI1, 1491 amino acids, UniProt Q96QZ7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ubiquitin carboxyl-terminal hydrolase 33 (USP33) — Ubiquitin carboxyl-terminal hydrolase 33 — human protein (gene USP33, 942 amino acids, UniProt Q8TEY7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome activator complex subunit 2 (PSME2) — Proteasome activator complex subunit 2 — human protein (gene PSME2, 239 amino acids, UniProt Q9UL46). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome activator complex subunit 1 (PSME1) — Proteasome activator complex subunit 1 — human protein (gene PSME1, 249 amino acids, UniProt Q06323). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome regulatory subunit 6B (PSMC4) — 26S proteasome regulatory subunit 6B — human protein (gene PSMC4, 418 amino acids, UniProt P43686). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome non-ATPase regulatory subunit 8 (PSMD8) — 26S proteasome non-ATPase regulatory subunit 8 — human protein (gene PSMD8, 350 amino acids, UniProt P48556). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome non-ATPase regulatory subunit 7 (PSMD7) — 26S proteasome non-ATPase regulatory subunit 7 — human protein (gene PSMD7, 324 amino acids, UniProt P51665). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome regulatory subunit 7 (PSMC2) — 26S proteasome regulatory subunit 7 — human protein (gene PSMC2, 433 amino acids, UniProt P35998). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome non-ATPase regulatory subunit 4 (PSMD4) — 26S proteasome non-ATPase regulatory subunit 4 — human protein (gene PSMD4, 377 amino acids, UniProt P55036). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome non-ATPase regulatory subunit 11 (PSMD11) — 26S proteasome non-ATPase regulatory subunit 11 — human protein (gene PSMD11, 422 amino acids, UniProt O00231). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome regulatory subunit 4 (PSMC1) — 26S proteasome regulatory subunit 4 — human protein (gene PSMC1, 440 amino acids, UniProt P62191). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome non-ATPase regulatory subunit 13 (PSMD13) — 26S proteasome non-ATPase regulatory subunit 13 — human protein (gene PSMD13, 376 amino acids, UniProt Q9UNM6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasome inhibitor PI31 subunit (PSMF1) — Proteasome inhibitor PI31 subunit — human protein (gene PSMF1, 271 amino acids, UniProt Q92530). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
UBX domain-containing protein 7 (UBXN7) — UBX domain-containing protein 7 — human protein (gene UBXN7, 489 amino acids, UniProt O94888). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome non-ATPase regulatory subunit 6 (PSMD6) — 26S proteasome non-ATPase regulatory subunit 6 — human protein (gene PSMD6, 389 amino acids, UniProt Q15008). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome regulatory subunit 10B (PSMC6) — 26S proteasome regulatory subunit 10B — human protein (gene PSMC6, 389 amino acids, UniProt P62333). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) — 26S proteasome non-ATPase regulatory subunit 3 — human protein (gene PSMD3, 534 amino acids, UniProt O43242). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proteasomal ubiquitin receptor ADRM1 (ADRM1) — Proteasomal ubiquitin receptor ADRM1 — human protein (gene ADRM1, 407 amino acids, UniProt Q16186). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome regulatory subunit 8 (PSMC5) — 26S proteasome regulatory subunit 8 — human protein (gene PSMC5, 406 amino acids, UniProt P62195). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome regulatory subunit 6A (PSMC3) — 26S proteasome regulatory subunit 6A — human protein (gene PSMC3, 439 amino acids, UniProt P17980). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome non-ATPase regulatory subunit 1 (PSMD1) — 26S proteasome non-ATPase regulatory subunit 1 — human protein (gene PSMD1, 953 amino acids, UniProt Q99460). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome non-ATPase regulatory subunit 12 (PSMD12) — 26S proteasome non-ATPase regulatory subunit 12 — human protein (gene PSMD12, 456 amino acids, UniProt O00232). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) — 26S proteasome non-ATPase regulatory subunit 2 — human protein (gene PSMD2, 908 amino acids, UniProt Q13200). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ubiquitin recognition factor in ER-associated degradation protein 1 (UFD1) — Ubiquitin recognition factor in ER-associated degradation protein 1 — human protein (gene UFD1, 307 amino acids, UniProt Q92890). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
F-box only protein 11 (FBXO11) — F-box only protein 11 — human protein (gene FBXO11, 927 amino acids, UniProt Q86XK2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Kelch-like protein 7 (KLHL7) — Kelch-like protein 7 — human protein (gene KLHL7, 586 amino acids, UniProt Q8IXQ5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
F-box only protein 22 (FBXO22) — F-box only protein 22 — human protein (gene FBXO22, 403 amino acids, UniProt Q8NEZ5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Anaphase-promoting complex subunit CDC26 (CDC26) — Anaphase-promoting complex subunit CDC26 — human protein (gene CDC26, 85 amino acids, UniProt Q8NHZ8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
F-box only protein 32 (FBXO32) — F-box only protein 32 — human protein (gene FBXO32, 355 amino acids, UniProt Q969P5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Anaphase-promoting complex subunit 1 (ANAPC1) — Anaphase-promoting complex subunit 1 — human protein (gene ANAPC1, 1944 amino acids, UniProt Q9H1A4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).