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Human proteins (AlphaFold) · Wnt, Notch & Hedgehog: 65 3D models

DNA, RNA, nucleic-acid drugs, gene editing, proteins and 300+ real PDB structures (real sizes 1–100 nm). Each one is a ready-made 3D model you can turn, recolour and place in a figure — open BioDiorama and type its name in the Library search.

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Intraflagellar transport protein 56 (IFT56) — Intraflagellar transport protein 56 — human protein (gene IFT56, 554 amino acids, UniProt A0AVF1). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transmembrane protein 131-like (TMEM131L) — Transmembrane protein 131-like — human protein (gene TMEM131L, 1609 amino acids, UniProt A2VDJ0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tax1-binding protein 3 (TAX1BP3) — Tax1-binding protein 3 — human protein (gene TAX1BP3, 124 amino acids, UniProt O14907). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
GDP-mannose 4,6 dehydratase (GMDS) — GDP-mannose 4,6 dehydratase — human protein (gene GMDS, 372 amino acids, UniProt O60547). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Sorbin and SH3 domain-containing protein 2 (SORBS2) — Sorbin and SH3 domain-containing protein 2 — human protein (gene SORBS2, 1100 amino acids, UniProt O94875). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transcription factor 7 (TCF7) — Transcription factor 7 — human protein (gene TCF7, 384 amino acids, UniProt P36402). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Methyl-CpG-binding protein 2 (MECP2) — Methyl-CpG-binding protein 2 — human protein (gene MECP2, 486 amino acids, UniProt P51608). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Growth arrest-specific protein 1 (GAS1) — Growth arrest-specific protein 1 — human protein (gene GAS1, 345 amino acids, UniProt P54826). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
EvC complex member EVC (EVC) — EvC complex member EVC — human protein (gene EVC, 992 amino acids, UniProt P57679). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Casein kinase II subunit beta (CSNK2B) — Casein kinase II subunit beta — human protein (gene CSNK2B, 215 amino acids, UniProt P67870). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Norrin (NDP) — Norrin — human protein (gene NDP, 133 amino acids, UniProt Q00604). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) — Inactive tyrosine-protein kinase transmembrane receptor ROR1 — human protein (gene ROR1, 937 amino acids, UniProt Q01973). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transducin-like enhancer protein 1 (TLE1) — Transducin-like enhancer protein 1 — human protein (gene TLE1, 770 amino acids, UniProt Q04724). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transducin-like enhancer protein 2 (TLE2) — Transducin-like enhancer protein 2 — human protein (gene TLE2, 743 amino acids, UniProt Q04725). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transducin-like enhancer protein 3 (TLE3) — Transducin-like enhancer protein 3 — human protein (gene TLE3, 772 amino acids, UniProt Q04726). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transducin-like enhancer protein 4 (TLE4) — Transducin-like enhancer protein 4 — human protein (gene TLE4, 773 amino acids, UniProt Q04727). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Recombining binding protein suppressor of hairless (RBPJ) — Recombining binding protein suppressor of hairless — human protein (gene RBPJ, 500 amino acids, UniProt Q06330). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
TLE family member 5 (TLE5) — TLE family member 5 — human protein (gene TLE5, 197 amino acids, UniProt Q08117). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transcription factor HES-1 (HES1) — Transcription factor HES-1 — human protein (gene HES1, 280 amino acids, UniProt Q14469). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Septin-2 (SEPTIN2) — Septin-2 — human protein (gene SEPTIN2, 361 amino acids, UniProt Q15019). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
R-spondin-4 (RSPO4) — R-spondin-4 — human protein (gene RSPO4, 234 amino acids, UniProt Q2I0M5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
R-spondin-1 (RSPO1) — R-spondin-1 — human protein (gene RSPO1, 263 amino acids, UniProt Q2MKA7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
ADP-ribosylation factor-like protein 13B (ARL13B) — ADP-ribosylation factor-like protein 13B — human protein (gene ARL13B, 428 amino acids, UniProt Q3SXY8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Cell adhesion molecule-related/down-regulated by oncogenes (CDON) — Cell adhesion molecule-related/down-regulated by oncogenes — human protein (gene CDON, 1287 amino acids, UniProt Q4KMG0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
APC membrane recruitment protein 1 (AMER1) — APC membrane recruitment protein 1 — human protein (gene AMER1, 1135 amino acids, UniProt Q5JTC6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Cilia- and flagella-associated protein 58 (CFAP58) — Cilia- and flagella-associated protein 58 — human protein (gene CFAP58, 872 amino acids, UniProt Q5T655). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM) — Palmitoleoyl-protein carboxylesterase NOTUM — human protein (gene NOTUM, 496 amino acids, UniProt Q6P988). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2) — Biogenesis of lysosome-related organelles complex 1 subunit 2 — human protein (gene BLOC1S2, 142 amino acids, UniProt Q6QNY1). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Protein LMBR1L (LMBR1L) — Protein LMBR1L — human protein (gene LMBR1L, 489 amino acids, UniProt Q6UX01). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Sclerostin domain-containing protein 1 (SOSTDC1) — Sclerostin domain-containing protein 1 — human protein (gene SOSTDC1, 206 amino acids, UniProt Q6X4U4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tubulin alpha-1A chain (TUBA1A) — Tubulin alpha-1A chain — human protein (gene TUBA1A, 451 amino acids, UniProt Q71U36). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Nephrocystin-3 (NPHP3) — Nephrocystin-3 — human protein (gene NPHP3, 1330 amino acids, UniProt Q7Z494). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Transcriptional regulator Kaiso (ZBTB33) — Transcriptional regulator Kaiso — human protein (gene ZBTB33, 672 amino acids, UniProt Q86T24). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Disheveled-associated activator of morphogenesis 2 (DAAM2) — Disheveled-associated activator of morphogenesis 2 — human protein (gene DAAM2, 1068 amino acids, UniProt Q86T65). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Limbin (EVC2) — Limbin — human protein (gene EVC2, 1308 amino acids, UniProt Q86UK5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Metalloprotease TIKI1 (TRABD2A) — Metalloprotease TIKI1 — human protein (gene TRABD2A, 505 amino acids, UniProt Q86V40). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase DTX1 (DTX1) — E3 ubiquitin-protein ligase DTX1 — human protein (gene DTX1, 620 amino acids, UniProt Q86Y01). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase MIB1 (MIB1) — E3 ubiquitin-protein ligase MIB1 — human protein (gene MIB1, 1006 amino acids, UniProt Q86YT6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Signal peptide, CUB and EGF-like domain-containing protein 1 (SCUBE1) — Signal peptide, CUB and EGF-like domain-containing protein 1 — human protein (gene SCUBE1, 988 amino acids, UniProt Q8IWY4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Signal peptide, CUB and EGF-like domain-containing protein 3 (SCUBE3) — Signal peptide, CUB and EGF-like domain-containing protein 3 — human protein (gene SCUBE3, 993 amino acids, UniProt Q8IX30). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Angiomotin-like protein 1 (AMOTL1) — Angiomotin-like protein 1 — human protein (gene AMOTL1, 956 amino acids, UniProt Q8IY63). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Mastermind-like protein 2 (MAML2) — Mastermind-like protein 2 — human protein (gene MAML2, 1156 amino acids, UniProt Q8IZL2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Protein APCDD1 (APCDD1) — Protein APCDD1 — human protein (gene APCDD1, 514 amino acids, UniProt Q8J025). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Glypican-2 (GPC2) — Glypican-2 — human protein (gene GPC2, 579 amino acids, UniProt Q8N158). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 SUMO-protein ligase PIAS4 (PIAS4) — E3 SUMO-protein ligase PIAS4 — human protein (gene PIAS4, 510 amino acids, UniProt Q8N2W9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
NF-kappa-B-activating protein (NKAP) — NF-kappa-B-activating protein — human protein (gene NKAP, 415 amino acids, UniProt Q8N5F7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
APC membrane recruitment protein 2 (AMER2) — APC membrane recruitment protein 2 — human protein (gene AMER2, 671 amino acids, UniProt Q8N7J2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase DTX3 (DTX3) — E3 ubiquitin-protein ligase DTX3 — human protein (gene DTX3, 347 amino acids, UniProt Q8N9I9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Kremen protein 2 (KREMEN2) — Kremen protein 2 — human protein (gene KREMEN2, 462 amino acids, UniProt Q8NCW0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Polypeptide N-acetylgalactosaminyltransferase 11 (GALNT11) — Polypeptide N-acetylgalactosaminyltransferase 11 — human protein (gene GALNT11, 608 amino acids, UniProt Q8NCW6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Cyclin-Y (CCNY) — Cyclin-Y — human protein (gene CCNY, 341 amino acids, UniProt Q8ND76). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Delta and Notch-like epidermal growth factor-related receptor (DNER) — Delta and Notch-like epidermal growth factor-related receptor — human protein (gene DNER, 737 amino acids, UniProt Q8NFT8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
RNA polymerase-associated protein LEO1 (LEO1) — RNA polymerase-associated protein LEO1 — human protein (gene LEO1, 666 amino acids, UniProt Q8WVC0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Gamma-secretase subunit APH-1B (APH1B) — Gamma-secretase subunit APH-1B — human protein (gene APH1B, 257 amino acids, UniProt Q8WW43). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Nicastrin (NCSTN) — Nicastrin — human protein (gene NCSTN, 709 amino acids, UniProt Q92542). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Mastermind-like protein 1 (MAML1) — Mastermind-like protein 1 — human protein (gene MAML1, 1016 amino acids, UniProt Q92585). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
E3 ubiquitin-protein ligase MIB2 (MIB2) — E3 ubiquitin-protein ligase MIB2 — human protein (gene MIB2, 955 amino acids, UniProt Q96AX9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Gamma-secretase subunit APH-1A (APH1A) — Gamma-secretase subunit APH-1A — human protein (gene APH1A, 265 amino acids, UniProt Q96BI3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ubiquitin thioesterase otulin (OTULIN) — Ubiquitin thioesterase otulin — human protein (gene OTULIN, 352 amino acids, UniProt Q96BN8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Tectonic-2 (TCTN2) — Tectonic-2 — human protein (gene TCTN2, 697 amino acids, UniProt Q96GX1). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Zinc finger BED domain-containing protein 3 (ZBED3) — Zinc finger BED domain-containing protein 3 — human protein (gene ZBED3, 234 amino acids, UniProt Q96IU2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Mastermind-like protein 3 (MAML3) — Mastermind-like protein 3 — human protein (gene MAML3, 1138 amino acids, UniProt Q96JK9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
RBPJ-interacting and tubulin-associated protein 1 (RITA1) — RBPJ-interacting and tubulin-associated protein 1 — human protein (gene RITA1, 269 amino acids, UniProt Q96K30). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Kremen protein 1 (KREMEN1) — Kremen protein 1 — human protein (gene KREMEN1, 473 amino acids, UniProt Q96MU8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Patched domain-containing protein 1 (PTCHD1) — Patched domain-containing protein 1 — human protein (gene PTCHD1, 888 amino acids, UniProt Q96NR3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).