Library › DNA & Proteins › Kinases & signalling (PDB)

Kinases & signalling (PDB): 90 3D models

DNA, RNA, nucleic-acid drugs, gene editing, proteins and 300+ real PDB structures (real sizes 1–100 nm). Each one is a ready-made 3D model you can turn, recolour and place in a figure — open BioDioRama and type its name in the Library search.

Open the 3D Studio

Camp-dependent protein kinase catalytic subunit (e.c.2.7.1.37)… — Camp-dependent protein kinase catalytic subunit (e.c.2.7.1.37) (protein kinase a) complexed with protein kinase inhibitor peptide fragment 5-24 (pki(5-24) isoelectric variant ca) and mn2+ adenylyl imidodiphosphate (mnamp-pnp) at ph 5.6 and 7c and 4c — X-ray structure, 1995 (PDB 1CDK), downloaded from the RCSB Protein Data Bank.
Mammalian catalytic subunit of camp-dependent protein kinase and an… — Structure of the mammalian catalytic subunit of camp-dependent protein kinase and an inhibitor peptide displays an open conformation — X-ray structure, 1994 (PDB 1CTP), downloaded from the RCSB Protein Data Bank.
Regulatory subunit of a cAMP-independent protein kinase A from… (6HYI) — Regulatory subunit of a camp-independent protein kinase a from trypanosoma cruzi at 1.4 a resolution in complex with inosine — X-ray structure, 2019 (PDB 6HYI), downloaded from the RCSB Protein Data Bank.
Regulatory subunit of a cAMP-independent protein kinase A from… (6FTF) — Regulatory subunit of a camp-independent protein kinase a from trypanosoma cruzi at 1.09 a resolution — X-ray structure, 2019 (PDB 6FTF), downloaded from the RCSB Protein Data Bank.
Myristylated catalytic subunit of camp-dependent protein kinase… — Crystal structures of the myristylated catalytic subunit of camp-dependent protein kinase reveal open and closed conformations — X-ray structure, 1994 (PDB 1CMK), downloaded from the RCSB Protein Data Bank.
CAMP bound PfPKA-R (141-441) — camp bound pfpka-r (141-441) — X-ray structure, 2016 (PDB 5KBF), downloaded from the RCSB Protein Data Bank.
PKA type I regulatory subunit bound with Rp-8-Br-cAMPS — Crystal structure of pka type i regulatory subunit bound with rp-8-br-camps — X-ray structure, 2010 (PDB 3PLQ), downloaded from the RCSB Protein Data Bank.
CK2 beta subunit crystallized in the presence of a p21WAF1 peptide — Structure of ck2 beta subunit crystallized in the presence of a p21waf1 peptide — X-ray structure, 2004 (PDB 1RQF), downloaded from the RCSB Protein Data Bank.
DDR1 bound to Dasatinib — Ddr1 bound to dasatinib — X-ray structure, 2018 (PDB 6BSD), downloaded from the RCSB Protein Data Bank.
Triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src… — structure of the triple (lys(beta)d3ala, asp(beta)c8ala, aspcd2ala) mutant of the src sh2 domain bound to the pqpyeeipi peptide — X-ray structure, 2002 (PDB 1KC2), downloaded from the RCSB Protein Data Bank.
Ephrin B4 (EphB4) Receptor Protein Kinase with Dasatinib — Crystal structure of ephrin b4 (ephb4) receptor protein kinase with dasatinib — X-ray structure, 2018 (PDB 6FNM), downloaded from the RCSB Protein Data Bank.
Fragment-based discovery of potent and selective DDR1/2 inhibitors — Fragment-based discovery of potent and selective ddr1/2 inhibitors — X-ray structure, 2015 (PDB 5BVW), downloaded from the RCSB Protein Data Bank.
Phosphotyrosine recognition domain SH2 of v-src — Crystal structure of the phosphotyrosine recognition domain sh2 of v-src complexed with tyrosine-phosphorylated peptides — X-ray structure, 1993 (PDB 1SHB), downloaded from the RCSB Protein Data Bank.
Unphosphorylated interleukin-2 tyrosine kinase catalytic domain — Crystal structure of the unphosphorylated interleukin-2 tyrosine kinase catalytic domain — X-ray structure, 2004 (PDB 1SNU), downloaded from the RCSB Protein Data Bank.
Ras-related c3 botulinum toxin substrate 1 isoform x2 from Naegleria… — Crystal structure of ras-related c3 botulinum toxin substrate 1 isoform x2 from naegleria fowleri in complex with gdp — X-ray structure, 2017 (PDB 5VCU), downloaded from the RCSB Protein Data Bank.
M-Ras P40D in complex with GDP — Crystal structure of m-ras p40d in complex with gdp — X-ray structure, 2010 (PDB 3KKQ), downloaded from the RCSB Protein Data Bank.
GDP-bound human M-RAS protein in crystal form II — Crystal structure of gdp-bound human m-ras protein in crystal form ii — X-ray structure, 2024 (PDB 9C1B), downloaded from the RCSB Protein Data Bank.
GDP-bound human M-RAS protein in crystal form I — Crystal structure of gdp-bound human m-ras protein in crystal form i — X-ray structure, 2024 (PDB 9C1A), downloaded from the RCSB Protein Data Bank.
GDP-bound mutant MRAS in complex with MRTX1133 — Crystal structure of gdp-bound mutant mras in complex with mrtx1133 — X-ray structure, 2026 (PDB 9O0P), downloaded from the RCSB Protein Data Bank.
Human Ras-like, family 12 protein in complex with GDP — Crystal structure of human ras-like, family 12 protein in complex with gdp — X-ray structure, 2008 (PDB 3C5C), downloaded from the RCSB Protein Data Bank.
Inhibition of Small GTPases by Stabilization of the GDP Complex, a… — Inhibition of small gtpases by stabilization of the gdp complex, a novel approach applied to rit1, a target for rheumatoid arthritis — X-ray structure, 2014 (PDB 4KLZ), downloaded from the RCSB Protein Data Bank.
Flagellin-FliS complex from Bacillus subtilis — Crystal structure of the flagellin-flis complex from bacillus subtilis — X-ray structure, 2017 (PDB 5MAW), downloaded from the RCSB Protein Data Bank.
Structural basis of the activation of the CC chemokine receptor 5 by… — Structural basis of the activation of the cc chemokine receptor 5 by a chemokine agonist — Cryo-EM structure, 2021 (PDB 7O7F), downloaded from the RCSB Protein Data Bank.
Human FLASH N-terminal domain — Crystal structure of human flash n-terminal domain — X-ray structure, 2017 (PDB 6ANO), downloaded from the RCSB Protein Data Bank.
Human FLASH N-terminal domain C54S/C83A (Crystal form 1) — Crystal structure of human flash n-terminal domain c54s/c83a (crystal form 1) — X-ray structure, 2017 (PDB 6AOZ), downloaded from the RCSB Protein Data Bank.
Human FLASH N-terminal domain C54S/C83A (Crystal form 2) — Crystal structure of human flash n-terminal domain c54s/c83a (crystal form 2) — X-ray structure, 2017 (PDB 6AP0), downloaded from the RCSB Protein Data Bank.
Heterotrimeric complex of phosducin/transducin beta-gamma — Heterotrimeric complex of phosducin/transducin beta-gamma — X-ray structure, 1998 (PDB 1A0R), downloaded from the RCSB Protein Data Bank.
Arrestin from bovine rod outer segments (1AYR) — Arrestin from bovine rod outer segments — X-ray structure, 1998 (PDB 1AYR), downloaded from the RCSB Protein Data Bank.
C-terminally truncated arrestin reveals mechanism of arrestin activation — Crystal structure of c-terminally truncated arrestin reveals mechanism of arrestin activation — X-ray structure, 2013 (PDB 4J2Q), downloaded from the RCSB Protein Data Bank.
Xenopus laevis arrestin 1 - P3121 crystal form — Crystal structure of xenopus laevis arrestin 1 - p3121 crystal form — X-ray structure, 2024 (PDB 8FUT), downloaded from the RCSB Protein Data Bank.
Native bovine arrestin 1 — Crystal structure of native bovine arrestin 1 — X-ray structure, 2021 (PDB 7JSM), downloaded from the RCSB Protein Data Bank.
Visual Arrestin — Crystal structure of visual arrestin — X-ray structure, 2012 (PDB 3UGX), downloaded from the RCSB Protein Data Bank.
Structure determinants of phosphoinositide 3-kinase inhibition by… (1E7U) — Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine — X-ray structure, 2000 (PDB 1E7U), downloaded from the RCSB Protein Data Bank.
Structure determinants of phosphoinositide 3-kinase inhibition by… (1E7V) — Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine — X-ray structure, 2000 (PDB 1E7V), downloaded from the RCSB Protein Data Bank.
Structure determinants of phosphoinositide 3-kinase inhibition by… (1E90) — Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine — X-ray structure, 2000 (PDB 1E90), downloaded from the RCSB Protein Data Bank.
ISH2 domain of human p85beta, Northeast Structural Genomics… — Crystal structure of ish2 domain of human p85beta, northeast structural genomics consortium target hr5531c — X-ray structure, 2010 (PDB 3MTT), downloaded from the RCSB Protein Data Bank.
Structure determinants of phosphoinositide 3-kinase inhibition by… (1E8W) — Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine — X-ray structure, 2000 (PDB 1E8W), downloaded from the RCSB Protein Data Bank.
Xenopus laevis arrestin 1 - P3221 crystal form — Crystal structure of xenopus laevis arrestin 1 - p3221 crystal form — X-ray structure, 2024 (PDB 8FUU), downloaded from the RCSB Protein Data Bank.
Kinase domain of RTKC8 from the choanoflagellate Monosiga brevicollis — Crystal structure of the kinase domain of rtkc8 from the choanoflagellate monosiga brevicollis — X-ray structure, 2023 (PDB 8E4T), downloaded from the RCSB Protein Data Bank.
Regulatory subunit of a cAMP-independent protein kinase A from… (6HYQ) — Regulatory subunit of a camp-independent protein kinase a from trypanosoma cruzi bound to guanosine — X-ray structure, 2019 (PDB 6HYQ), downloaded from the RCSB Protein Data Bank.
Flagellin-FliS complex from Bacillus subtilis crystallized in… — Crystal structure of the flagellin-flis complex from bacillus subtilis crystallized in spacegroup p22121 — X-ray structure, 2018 (PDB 6GOW), downloaded from the RCSB Protein Data Bank.
GDP-bound Gs heterotrimer — Structure of the gdp-bound gs heterotrimer — X-ray structure, 2019 (PDB 6EG8), downloaded from the RCSB Protein Data Bank.
Visual arrestin mutant - R175E — Visual arrestin mutant - r175e — X-ray structure, 2015 (PDB 4ZRG), downloaded from the RCSB Protein Data Bank.
P44 (Splice Variant of Visual Arrestin) — Crystal structure of p44 (splice variant of visual arrestin) — X-ray structure, 2012 (PDB 3UGU), downloaded from the RCSB Protein Data Bank.
Cryptosporidium parvum small GTPase RAB1A — Crystal structure of cryptosporidium parvum small gtpase rab1a — X-ray structure, 2007 (PDB 2RHD), downloaded from the RCSB Protein Data Bank.
M-Ras in complex with GDP — Crystal structure of m-ras in complex with gdp — X-ray structure, 2005 (PDB 1X1R), downloaded from the RCSB Protein Data Bank.
Beta-gamma dimer of the heterotrimeric g-protein transducin — Beta-gamma dimer of the heterotrimeric g-protein transducin — X-ray structure, 1997 (PDB 1TBG), downloaded from the RCSB Protein Data Bank.
Binding of a high affinity phosphotyrosyl peptide to the src SH2… (1SPR) — Binding of a high affinity phosphotyrosyl peptide to the src sh2 domain: crystal structures of the complexed and peptide-free forms — X-ray structure, 1994 (PDB 1SPR), downloaded from the RCSB Protein Data Bank.
Cocrystal structure of urea-substituted phosphopeptide complex — Cocrystal structure of urea-substituted phosphopeptide complex — X-ray structure, 1998 (PDB 1SKJ), downloaded from the RCSB Protein Data Bank.
Arrestin from bovine rod outer segments (1CF1) — Arrestin from bovine rod outer segments — X-ray structure, 1999 (PDB 1CF1), downloaded from the RCSB Protein Data Bank.
Structural insights into phoshoinositide 3-KINASE enzymatic… — Structural insights into phoshoinositide 3-kinase enzymatic mechanism and signalling — X-ray structure, 2000 (PDB 1E8X), downloaded from the RCSB Protein Data Bank.
Achieving multi-isoform PI3K inhibition in a series of substituted… — Achieving multi-isoform pi3k inhibition in a series of substituted 3,4-dihydro-2h-benzo[1,4]oxazines — X-ray structure, 2008 (PDB 3DPD), downloaded from the RCSB Protein Data Bank.
Pi3K gamma with a potent inhibitor: GSK2126458 — Structure of pi3k gamma with a potent inhibitor: gsk2126458 — X-ray structure, 2010 (PDB 3L08), downloaded from the RCSB Protein Data Bank.
Cydia Pomonella PTP-2 phosphatase — Crystal structure of cydia pomonella ptp-2 phosphatase — X-ray structure, 2019 (PDB 6I28), downloaded from the RCSB Protein Data Bank.
Tk-PTP in the inactive form — Crystal structure of tk-ptp in the inactive form — X-ray structure, 2018 (PDB 5Z59), downloaded from the RCSB Protein Data Bank.
Complex of the archaeal sulfolobus PTP-fold phosphatase with… (2DXP) — Crystal structure of the complex of the archaeal sulfolobus ptp-fold phosphatase with phosphopeptides a-(p)y-r — X-ray structure, 2007 (PDB 2DXP), downloaded from the RCSB Protein Data Bank.
Complex of the archaeal sulfolobus PTP-fold phosphatase with… (2I6J) — Crystal structure of the complex of the archaeal sulfolobus ptp-fold phosphatase with phosphate ion — X-ray structure, 2007 (PDB 2I6J), downloaded from the RCSB Protein Data Bank.
Archaeal sulfolobus PTP-fold phosphatase — crystal structures of the archaeal sulfolobus ptp-fold phosphatase — X-ray structure, 2007 (PDB 2I6I), downloaded from the RCSB Protein Data Bank.
Complex of the archaeal sulfolobus PTP-fold phosphatase with pNPP — Crystal structure of the complex of the archaeal sulfolobus ptp-fold phosphatase with pnpp — X-ray structure, 2007 (PDB 2I6P), downloaded from the RCSB Protein Data Bank.
Complexes of the archaeal sulfolobus PTP-fold phosphatase with Tungstate — Crystal structure of the complexes of the archaeal sulfolobus ptp-fold phosphatase with tungstate — X-ray structure, 2007 (PDB 2I6M), downloaded from the RCSB Protein Data Bank.
PTP-like myo-inositol phosphatase from Legionella pneumophila str. Paris — Structure of the ptp-like myo-inositol phosphatase from legionella pneumophila str. paris in complex with myo-inositol hexakisphosphate — X-ray structure, 2022 (PDB 7SDB), downloaded from the RCSB Protein Data Bank.
Calmodulin/nematode CA2+/Calmodulin dependent kinase kinase fragment — Calmodulin/nematode ca2+/calmodulin dependent kinase kinase fragment — X-ray structure, 2001 (PDB 1IQ5), downloaded from the RCSB Protein Data Bank.
Pb-bound Calmodulin — Crystal structure of pb-bound calmodulin — X-ray structure, 2003 (PDB 1N0Y), downloaded from the RCSB Protein Data Bank.
Paramecium tetraurelia calmodulin at 1.8 angstroms resolution — Structure of paramecium tetraurelia calmodulin at 1.8 angstroms resolution — X-ray structure, 1993 (PDB 1CLM), downloaded from the RCSB Protein Data Bank.
Recombinant paramecium tetraurelia calmodulin at 1.68 angstroms… — Crystal structure of recombinant paramecium tetraurelia calmodulin at 1.68 angstroms resolution — X-ray structure, 1993 (PDB 1OSA), downloaded from the RCSB Protein Data Bank.
Bovine brain Ca++ calmodulin in a compact form — Crystal structure of bovine brain ca++ calmodulin in a compact form — X-ray structure, 2003 (PDB 1PRW), downloaded from the RCSB Protein Data Bank.
Putative calcium/calmodulin dependent protein kinase II association… — Crystal structure of putative calcium/calmodulin dependent protein kinase ii association domain (np_636218.1) from xanthomonas campestris at 1.70 a resolution — X-ray structure, 2009 (PDB 3H51), downloaded from the RCSB Protein Data Bank.
Ca(2+)-Calmodulin from Paramecium tetraurelia qFit disorder model — Ca(2+)-calmodulin from paramecium tetraurelia qfit disorder model — X-ray structure, 2015 (PDB 5E1P), downloaded from the RCSB Protein Data Bank.
14-3-3 protein from cryptosporidium parvum (cgd1_2980) — Crystal structure of a 14-3-3 protein from cryptosporidium parvum (cgd1_2980) — X-ray structure, 2008 (PDB 3EFZ), downloaded from the RCSB Protein Data Bank.
Putative 14-3-3 protein from Cryptosporidium parvum, cgd7_2470 — Crystal structure of a putative 14-3-3 protein from cryptosporidium parvum, cgd7_2470 — X-ray structure, 2007 (PDB 2O8P), downloaded from the RCSB Protein Data Bank.
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex (1O9E) — Structural view of a fungal toxin acting on a 14-3-3 regulatory complex — X-ray structure, 2003 (PDB 1O9E), downloaded from the RCSB Protein Data Bank.
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex (1O9C) — Structural view of a fungal toxin acting on a 14-3-3 regulatory complex — X-ray structure, 2003 (PDB 1O9C), downloaded from the RCSB Protein Data Bank.
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex (1O9F) — Structural view of a fungal toxin acting on a 14-3-3 regulatory complex — X-ray structure, 2003 (PDB 1O9F), downloaded from the RCSB Protein Data Bank.
14-3-3 protein tau isoform — 14-3-3 protein tau isoform — X-ray structure, 2016 (PDB 5IQP), downloaded from the RCSB Protein Data Bank.
14-3-3 Protein Theta (Human) Complexed to Peptide — 14-3-3 protein theta (human) complexed to peptide — X-ray structure, 2005 (PDB 2BTP), downloaded from the RCSB Protein Data Bank.
Signaling molecule — Crystal structure of a signaling molecule — X-ray structure, 2008 (PDB 2QMS), downloaded from the RCSB Protein Data Bank.
Growth factor receptor binding protein SH2 domain (human) — Growth factor receptor binding protein sh2 domain (human) complexed with a phosphotyrosyl derivative — X-ray structure, 1999 (PDB 1CJ1), downloaded from the RCSB Protein Data Bank.
Src Homology-2 domain of the adapter protein SH2-B — Crystal structure of the src homology-2 domain of the adapter protein sh2-b — X-ray structure, 2006 (PDB 2HDV), downloaded from the RCSB Protein Data Bank.
Grb14 SH2 domain — Crystal structure of the grb14 sh2 domain — X-ray structure, 2005 (PDB 2AUG), downloaded from the RCSB Protein Data Bank.
Structural Basis for Differential Recognition of Tyrosine… (1R1S) — Structural basis for differential recognition of tyrosine phosphorylated sites in the linker for activation of t cells (lat) by the adaptor protein gads — X-ray structure, 2004 (PDB 1R1S), downloaded from the RCSB Protein Data Bank.
Src SH2 domain bound to doubly phosphorylated peptide PQpYEpYIPI — Crystal structure of src sh2 domain bound to doubly phosphorylated peptide pqpyepyipi — X-ray structure, 2003 (PDB 1NZL), downloaded from the RCSB Protein Data Bank.
SP-PTP, low molecular weight protein tyrosine phosphatase from… — Crystal structure of sp-ptp, low molecular weight protein tyrosine phosphatase from streptococcus pyogenes — X-ray structure, 2016 (PDB 5GOT), downloaded from the RCSB Protein Data Bank.
Structural insights into phosphoinositide 3-kinase activation by the… — Structural insights into phosphoinositide 3-kinase activation by the influenza a virus ns1 protein — X-ray structure, 2010 (PDB 3L4Q), downloaded from the RCSB Protein Data Bank.
Cryptosporidium parvum 14-3-3 protein in complex with peptide — crystal structure of cryptosporidium parvum 14-3-3 protein in complex with peptide — X-ray structure, 2006 (PDB 2NPM), downloaded from the RCSB Protein Data Bank.
Binding of a high affinity phosphotyrosyl peptide to the src SH2… (1SPS) — Binding of a high affinity phosphotyrosyl peptide to the src sh2 domain: crystal structures of the complexed and peptide-free forms — X-ray structure, 1994 (PDB 1SPS), downloaded from the RCSB Protein Data Bank.
Potato Calmodulin PCM6 — Crystal structure of potato calmodulin pcm6 — X-ray structure, 2004 (PDB 1RFJ), downloaded from the RCSB Protein Data Bank.
Structural Basis for Differential Recognition of Tyrosine… (1R1P) — Structural basis for differential recognition of tyrosine phosphorylated sites in the linker for activation of t cells (lat) by the adaptor protein gads — X-ray structure, 2004 (PDB 1R1P), downloaded from the RCSB Protein Data Bank.
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex (1O9D) — Structural view of a fungal toxin acting on a 14-3-3 regulatory complex — X-ray structure, 2003 (PDB 1O9D), downloaded from the RCSB Protein Data Bank.
The 1.0 angstrom crystal structure of CA+2 bound calmodulin — The 1.0 angstrom crystal structure of ca+2 bound calmodulin — X-ray structure, 2000 (PDB 1EXR), downloaded from the RCSB Protein Data Bank.
Xlp protein sap — Crystal structure of the xlp protein sap — X-ray structure, 1999 (PDB 1D1Z), downloaded from the RCSB Protein Data Bank.