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Plasmodium falciparum proteins (AlphaFold) · Reference proteome: 70 3D models

DNA, RNA, nucleic-acid drugs, gene editing, proteins and 300+ real PDB structures (real sizes 1–100 nm). Each one is a ready-made 3D model you can turn, recolour and place in a figure — open BioDiorama and type its name in the Library search.

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DNA sliding clamp PCNA1 (PCNA1, P. falciparum) — DNA sliding clamp PCNA1 — malaria parasite (Plasmodium falciparum) protein (gene PCNA1, 274 amino acids, UniProt P61074). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Thioredoxin reductase (TRXR, P. falciparum) — Thioredoxin reductase — malaria parasite (Plasmodium falciparum) protein (gene TRXR, 617 amino acids, UniProt P61076). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Calcium-dependent protein kinase 1 (CDPK1, P. falciparum) — Calcium-dependent protein kinase 1 — malaria parasite (Plasmodium falciparum) protein (gene CDPK1, 524 amino acids, UniProt P62344). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ornithine aminotransferase (OAT, P. falciparum) — Ornithine aminotransferase — malaria parasite (Plasmodium falciparum) protein (gene OAT, 414 amino acids, UniProt Q6LFH8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Falcilysin (FLN, P. falciparum) — Falcilysin — malaria parasite (Plasmodium falciparum) protein (gene FLN, 1193 amino acids, UniProt Q76NL8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
V-type proton ATPase catalytic subunit A (vapA, P. falciparum) — V-type proton ATPase catalytic subunit A — malaria parasite (Plasmodium falciparum) protein (gene vapA, 611 amino acids, UniProt Q76NM6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ras-related protein Rab-5B (RAB5b, P. falciparum) — Ras-related protein Rab-5B — malaria parasite (Plasmodium falciparum) protein (gene RAB5b, 207 amino acids, UniProt Q76NM7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Circumsporozoite protein (CSP, P. falciparum) — Circumsporozoite protein — malaria parasite (Plasmodium falciparum) protein (gene CSP, 397 amino acids, UniProt Q7K740). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
DNA sliding clamp PCNA2 (PCNA2, P. falciparum) — DNA sliding clamp PCNA2 — malaria parasite (Plasmodium falciparum) protein (gene PCNA2, 264 amino acids, UniProt Q7KQJ9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Fructose-bisphosphate aldolase (FBPA, P. falciparum) — Fructose-bisphosphate aldolase — malaria parasite (Plasmodium falciparum) protein (gene FBPA, 369 amino acids, UniProt Q7KQL9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Plasmepsin I (PMI, P. falciparum) — Plasmepsin I — malaria parasite (Plasmodium falciparum) protein (gene PMI, 452 amino acids, UniProt Q7KQM4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Hexose transporter 1 (HT1, P. falciparum) — Hexose transporter 1 — malaria parasite (Plasmodium falciparum) protein (gene HT1, 504 amino acids, UniProt Q7KWJ5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Merozoite surface protein 1 (MSP1, P. falciparum) — Merozoite surface protein 1 — malaria parasite (Plasmodium falciparum) protein (gene MSP1, 1720 amino acids, UniProt Q8I0U8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Subtilisin-like protease 1 (SUB1, P. falciparum) — Subtilisin-like protease 1 — malaria parasite (Plasmodium falciparum) protein (gene SUB1, 688 amino acids, UniProt Q8I0V0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
GTP:AMP phosphotransferase (GAK, P. falciparum) — GTP:AMP phosphotransferase — malaria parasite (Plasmodium falciparum) protein (gene GAK, 229 amino acids, UniProt Q8I1T1). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Niemann-Pick type C1-related protein (NCR1, P. falciparum) — Niemann-Pick type C1-related protein — malaria parasite (Plasmodium falciparum) protein (gene NCR1, 1470 amino acids, UniProt Q8I266). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, apicoplast (LytB, P. falciparum) — 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, apicoplast — malaria parasite (Plasmodium falciparum) protein (gene LytB, 535 amino acids, UniProt Q8I295). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
CX3CL1-binding protein 1 (CBP1, P. falciparum) — CX3CL1-binding protein 1 — malaria parasite (Plasmodium falciparum) protein (gene CBP1, 243 amino acids, UniProt Q8I2D9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Aspartyl aminopeptidase (M18AAP, P. falciparum) — Aspartyl aminopeptidase — malaria parasite (Plasmodium falciparum) protein (gene M18AAP, 570 amino acids, UniProt Q8I2J3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Glideosome-associated protein 50 (GAP50, P. falciparum) — Glideosome-associated protein 50 — malaria parasite (Plasmodium falciparum) protein (gene GAP50, 396 amino acids, UniProt Q8I2X3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Falstatin (ICP, P. falciparum) — Falstatin — malaria parasite (Plasmodium falciparum) protein (gene ICP, 413 amino acids, UniProt Q8I333). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Arginase (ARG, P. falciparum) — Arginase — malaria parasite (Plasmodium falciparum) protein (gene ARG, 411 amino acids, UniProt Q8I384). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
High molecular weight rhoptry protein 3 (RhopH3, P. falciparum) — High molecular weight rhoptry protein 3 — malaria parasite (Plasmodium falciparum) protein (gene RhopH3, 897 amino acids, UniProt Q8I395). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Purine nucleoside phosphorylase (PNP, P. falciparum) — Purine nucleoside phosphorylase — malaria parasite (Plasmodium falciparum) protein (gene PNP, 245 amino acids, UniProt Q8I3X4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Chitinase (CHT1, P. falciparum) — Chitinase — malaria parasite (Plasmodium falciparum) protein (gene CHT1, 378 amino acids, UniProt Q8I4R4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Peptidyl-prolyl cis-trans isomerase FKBP35 (FKBP35, P. falciparum) — Peptidyl-prolyl cis-trans isomerase FKBP35 — malaria parasite (Plasmodium falciparum) protein (gene FKBP35, 304 amino acids, UniProt Q8I4V8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Actin-1 (ACT1, P. falciparum) — Actin-1 — malaria parasite (Plasmodium falciparum) protein (gene ACT1, 376 amino acids, UniProt Q8I4X0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Merozoite surface protein 9 (MSP9, P. falciparum) — Merozoite surface protein 9 — malaria parasite (Plasmodium falciparum) protein (gene MSP9, 743 amino acids, UniProt Q8I5D2). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Vacuolar iron transporter (VIT, P. falciparum) — Vacuolar iron transporter — malaria parasite (Plasmodium falciparum) protein (gene VIT, 273 amino acids, UniProt Q8I5I0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Glideosome-associated protein 45 (GAP45, P. falciparum) — Glideosome-associated protein 45 — malaria parasite (Plasmodium falciparum) protein (gene GAP45, 204 amino acids, UniProt Q8I5I8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Thioredoxin peroxidase 2 (Trx-Px2, P. falciparum) — Thioredoxin peroxidase 2 — malaria parasite (Plasmodium falciparum) protein (gene Trx-Px2, 216 amino acids, UniProt Q8I5Q6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Proline--tRNA ligase (proRS, P. falciparum) — Proline--tRNA ligase — malaria parasite (Plasmodium falciparum) protein (gene proRS, 746 amino acids, UniProt Q8I5R7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
cGMP-specific 3',5'-cyclic phosphodiesterase alpha (PDEalpha, P. falciparum) — cGMP-specific 3',5'-cyclic phosphodiesterase alpha — malaria parasite (Plasmodium falciparum) protein (gene PDEalpha, 954 amino acids, UniProt Q8I5V4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Falcipain-2a (FP2A, P. falciparum) — Falcipain-2a — malaria parasite (Plasmodium falciparum) protein (gene FP2A, 484 amino acids, UniProt Q8I6U4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Falcipain-2b (FP2B, P. falciparum) — Falcipain-2b — malaria parasite (Plasmodium falciparum) protein (gene FP2B, 482 amino acids, UniProt Q8I6U5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Plasmepsin II (PMII, P. falciparum) — Plasmepsin II — malaria parasite (Plasmodium falciparum) protein (gene PMII, 453 amino acids, UniProt Q8I6V3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Plasmepsin V (PMV, P. falciparum) — Plasmepsin V — malaria parasite (Plasmodium falciparum) protein (gene PMV, 590 amino acids, UniProt Q8I6Z5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase beta (PDEbeta, P. falciparum) — Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase beta — malaria parasite (Plasmodium falciparum) protein (gene PDEbeta, 1139 amino acids, UniProt Q8I6Z7). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
cGMP-dependent protein kinase (PKG, P. falciparum) — cGMP-dependent protein kinase — malaria parasite (Plasmodium falciparum) protein (gene PKG, 853 amino acids, UniProt Q8I719). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Plasmepsin X (PMX, P. falciparum) — Plasmepsin X — malaria parasite (Plasmodium falciparum) protein (gene PMX, 573 amino acids, UniProt Q8IAS0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Calcium-dependent protein kinase 4 (CDPK4, P. falciparum) — Calcium-dependent protein kinase 4 — malaria parasite (Plasmodium falciparum) protein (gene CDPK4, 528 amino acids, UniProt Q8IBS5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Cysteine desulfurase SufS (SufS, P. falciparum) — Cysteine desulfurase SufS — malaria parasite (Plasmodium falciparum) protein (gene SufS, 546 amino acids, UniProt Q8IBT4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Chloroquine resistance transporter (CRT, P. falciparum) — Chloroquine resistance transporter — malaria parasite (Plasmodium falciparum) protein (gene CRT, 424 amino acids, UniProt Q8IBZ9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Calcium-dependent protein kinase 2 (CDPK2, P. falciparum) — Calcium-dependent protein kinase 2 — malaria parasite (Plasmodium falciparum) protein (gene CDPK2, 513 amino acids, UniProt Q8ICR0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
ABC transporter ATM1 (ABCB6, P. falciparum) — ABC transporter ATM1 — malaria parasite (Plasmodium falciparum) protein (gene ABCB6, 1049 amino acids, UniProt Q8IDH9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Nucleoside transporter 1 (NT1, P. falciparum) — Nucleoside transporter 1 — malaria parasite (Plasmodium falciparum) protein (gene NT1, 422 amino acids, UniProt Q8IDM6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Female gametocyte surface protein P47 (P47, P. falciparum) — Female gametocyte surface protein P47 — malaria parasite (Plasmodium falciparum) protein (gene P47, 439 amino acids, UniProt Q8IDN0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Thioredoxin 2 (TRX2, P. falciparum) — Thioredoxin 2 — malaria parasite (Plasmodium falciparum) protein (gene TRX2, 157 amino acids, UniProt Q8IDP4). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Phosphoethanolamine N-methyltransferase (PMT, P. falciparum) — Phosphoethanolamine N-methyltransferase — malaria parasite (Plasmodium falciparum) protein (gene PMT, 266 amino acids, UniProt Q8IDQ9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Myosin-A (MyoA, P. falciparum) — Myosin-A — malaria parasite (Plasmodium falciparum) protein (gene MyoA, 818 amino acids, UniProt Q8IDR3). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Apurinic-apyrimidinic endonuclease 1 (APN1, P. falciparum) — Apurinic-apyrimidinic endonuclease 1 — malaria parasite (Plasmodium falciparum) protein (gene APN1, 597 amino acids, UniProt Q8IE02). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Signal peptidase complex catalytic subunit SEC11 (SEC11, P. falciparum) — Signal peptidase complex catalytic subunit SEC11 — malaria parasite (Plasmodium falciparum) protein (gene SEC11, 184 amino acids, UniProt Q8IE14). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
NAD-dependent protein deacylase Sir2A (Sir2A, P. falciparum) — NAD-dependent protein deacylase Sir2A — malaria parasite (Plasmodium falciparum) protein (gene Sir2A, 273 amino acids, UniProt Q8IE47). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Variant-silencing SET domain-containing protein (SETVS, P. falciparum) — Variant-silencing SET domain-containing protein — malaria parasite (Plasmodium falciparum) protein (gene SETVS, 2548 amino acids, UniProt Q8IE95). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Lipoate--protein ligase 1 (LipL1, P. falciparum) — Lipoate--protein ligase 1 — malaria parasite (Plasmodium falciparum) protein (gene LipL1, 408 amino acids, UniProt Q8IEG9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
CX3CL1-binding protein 2 (CBP2, P. falciparum) — CX3CL1-binding protein 2 — malaria parasite (Plasmodium falciparum) protein (gene CBP2, 245 amino acids, UniProt Q8IEJ0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Cysteine-rich protective antigen (CyRPA, P. falciparum) — Cysteine-rich protective antigen — malaria parasite (Plasmodium falciparum) protein (gene CyRPA, 362 amino acids, UniProt Q8IFM8). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Subtilisin-like protease 2 (SUB2, P. falciparum) — Subtilisin-like protease 2 — malaria parasite (Plasmodium falciparum) protein (gene SUB2, 1341 amino acids, UniProt Q8IHZ5). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
P-type sodium-transporting ATPase4 (ATP4, P. falciparum) — P-type sodium-transporting ATPase4 — malaria parasite (Plasmodium falciparum) protein (gene ATP4, 1264 amino acids, UniProt A0A143ZZK9). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
IMP-specific 5'-nucleotidase 1 (ISN1, P. falciparum) — IMP-specific 5'-nucleotidase 1 — malaria parasite (Plasmodium falciparum) protein (gene ISN1, 444 amino acids, UniProt A0A144A134). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Aminopeptidase P (APP, P. falciparum) — Aminopeptidase P — malaria parasite (Plasmodium falciparum) protein (gene APP, 777 amino acids, UniProt A0A144A2H0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Calcium-dependent protein kinase 5 (CDPK5, P. falciparum) — Calcium-dependent protein kinase 5 — malaria parasite (Plasmodium falciparum) protein (gene CDPK5, 568 amino acids, UniProt A0A5K1K8H0). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
14-3-3 protein I (14-3-3I, P. falciparum) — 14-3-3 protein I — malaria parasite (Plasmodium falciparum) protein (gene 14-3-3I, 262 amino acids, UniProt C0H4V6). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Pyridoxal 5'-phosphate synthase subunit Pdx1 (pdx1, P. falciparum) — Pyridoxal 5'-phosphate synthase subunit Pdx1 — malaria parasite (Plasmodium falciparum) protein (gene pdx1, 301 amino acids, UniProt C6KT50). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Ferredoxin--NADP reductase, apicoplast (FNR, P. falciparum) — Ferredoxin--NADP reductase, apicoplast — malaria parasite (Plasmodium falciparum) protein (gene FNR, 371 amino acids, UniProt C6KT68). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Dual specificity protein phosphatase YVH1 (YVH1, P. falciparum) — Dual specificity protein phosphatase YVH1 — malaria parasite (Plasmodium falciparum) protein (gene YVH1, 575 amino acids, UniProt O77334). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
DNA-(apurinic or apyrimidinic site) endonuclease (APE1, P. falciparum) — DNA-(apurinic or apyrimidinic site) endonuclease — malaria parasite (Plasmodium falciparum) protein (gene APE1, 617 amino acids, UniProt O97240). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Rh5-interacting protein (RIPR, P. falciparum) — Rh5-interacting protein — malaria parasite (Plasmodium falciparum) protein (gene RIPR, 1086 amino acids, UniProt O97302). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
EMP1 trafficking protein-7 (PTP7, P. falciparum) — EMP1 trafficking protein-7 — malaria parasite (Plasmodium falciparum) protein (gene PTP7, 317 amino acids, UniProt O97336). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).
Falcipain-1 (FP1, P. falciparum) — Falcipain-1 — malaria parasite (Plasmodium falciparum) protein (gene FP1, 569 amino acids, UniProt P25805). AlphaFold-predicted 3D structure; by default coloured by model confidence (blue = very high, orange = very low, typical of disordered regions).